Novel α-2-macroglobulin cleaved fragments as biomarkers of early liver fibrosis in patients with chronic hepatitis C

被引：0
作者：
Batxelli-Molina, Isabelle [1 ]
Calvayrac-Pawlowski, Sophie [1 ]
Moulin, Veronique [1 ]
Lapalus, Martine [2 ,3 ]
Hem, Sonia [4 ]
Laune, Daniel [1 ]
Asselah, Tarik [2 ,3 ]
Jardin-Watelet, Benedicte [1 ]
机构：
[1] SysDiag UMR 3145 CNRS Biorad, Montpellier, France
[2] Univ Paris Diderot, Hop Beaujon, Serv Hepatol, Clichy, France
[3] Univ Paris Diderot, Hop Beaujon, CRB3, INSERM,U773, Clichy, France
[4] INRA, UR1199, Lab Prote Fonct, F-34060 Montpellier, France
来源：
FUTURE VIROLOGY | 2015年 / 10卷 / 01期
关键词：
40 kDa isoforms; -2; macroglobulin; chronic hepatitis C; early diagnosis; liver fibrosis; serum; BIOCHEMICAL MARKERS; COST-EFFECTIVENESS; DOMAIN-STRUCTURE; HCV; VIRUS; BINDING; SEQUENCE; PROTEIN; ALPHA(2)-MACROGLOBULIN; EXPRESSION;
D O I：
10.2217/fvl.14.98
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: Liver biopsy is considered the gold standard for the diagnosis and staging of hepatic fibrosis in patients with chronic hepatitis C and is now progressively replaced by noninvasive procedures. We aimed at improving -2-macroglobulin diagnostic value for liver fibrosis by identifying new isoforms that may be specifically related to early stages of the pathology. Materials & methods: -2-Macroglobulin isoforms were characterized in serum samples from patients with chronic hepatitis C and mild (F1) to moderate (F2) fibrosis by proteomic methods. Results: New biological 40 kDa C-terminal -2-macroglobulin fragments were identified as potential biomarkers of early fibrosis (fold change = 1.55; p < 0.01). Conclusion: The serum concentration of -2-macroglobulin fragments allows a better differentiation of F1 and F2 fibrosis stages than total -2-macroglobulin isoforms.
引用
收藏
页码：5 / 16
页数：12
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