Intriguing Pen-Strut Low-Intensity Area Detected by Optical Coherence Tomography After Coronary Stent Deployment

被引：63

作者：

Teramoto, Tomohiko

Ikeno, Fumiaki ^{[1
]}

Otake, Hiromasa

Lyons, Jennifer K.

van Beusekom, Heleen M. M. ^{[2
]}

Fearon, William F.

Yeung, Alan C.

机构：

[1] Stanford Univ, Dept Cardiovasc Med, Div Cardiovasc Med, Stanford, CA 94305 USA

[2] Erasmus MC, Dept Expt Cardiol, Rotterdam, Netherlands

来源：

CIRCULATION JOURNAL | 2010年 / 74卷 / 06期

关键词：

Drug-eluting stent (DES); Optical coherence tomography (OCT); Restenosis; DRUG-ELUTING STENTS; EXTRACELLULAR-MATRIX; PACLITAXEL; SIROLIMUS;

D O I：

10.1253/circj.CJ-10-0189

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Although pen-strut low-intensity area (PLIA) is frequently observed on post-stenting optical coherence tomography (OCT) images, the histology associated with PLIA is undocumented. Methods and Results: The 36 porcine coronary lesions treated with bare-metal (BMS: n=16) or drug-eluting (DES: n=20) stents were assessed by OCT and histology at 28 days. DES showed a significantly higher incidence of PLIA than BMS. Also, +PLIA stents had greater neointima than PLIA stents. Histological analysis revealed the existence of fibrinoid and proteoglycans at the site of PLIA. Conclusions: PLIA might be represented by the presence of fibrinoid and proteoglycans, and associated with neointimal proliferation after stenting. (Circ J 2010; 74: 1257-1259)

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收藏

页码：1257 / 1259

页数：3

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