Stevens-Johnson syndrome and toxic epidermal necrolysis associated with increased risk of developing psychiatric disorders: A retrospective population-based cohort study in Taiwan

被引：3

作者：

Chiang, Chien-Ping ^{[1
,2
]}

Hung, Chih-Tsung ^{[1
,3
]}

Chen, Yi-Hsien ^{[1
]}

Chen, Chih-Yu ^{[1
,2
]}

Soong, Chen-Yeu ^{[1
]}

Liu, Sheng-Wen ^{[1
]}

Liu, Hsi-Ling ^{[1
]}

Ma, Jun ^{[1
]}

Chung, Chi-Hsiang ^{[4
,5
]}

Tsao, Chang-Huei ^{[6
,7
]}

Sun, Chien-An ^{[8
,9
]}

Chien, Wu-Chien ^{[4
,6
,10
]}

Wang, Wei-Ming ^{[1
]}

机构：

[1] Triserv Gen Hosp, Natl Def Med Ctr, Dept Dermatol, Taipei, Taiwan

[2] Natl Def Med Ctr, Dept Biochem, Taipei, Taiwan

[3] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan

[4] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan

[5] Taiwanese Injury Prevent & Safety Promot Assoc, Taipei, Taiwan

[6] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med Res, 7115R,325,Sect 2,Cheng Kung Rd, Taipei 114, Taiwan

[7] Natl Def Med Ctr, Dept Microbiol & Immunol, Taipei, Taiwan

[8] Fu Jen Catholic Univ, Coll Med, Dept Publ Hlth, New Taipei, Taiwan

[9] Fu Jen Catholic Univ, Coll Med, Big Data Res Ctr, New Taipei, Taiwan

[10] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan

来源：

JOURNAL OF DERMATOLOGY | 2022年 / 49卷 / 10期

关键词：

anxiety; bipolar; major depressive disorder; manic disorder; psychiatric disorders; schizophrenia; Stevens-Johnson syndrome; toxic epidermal necrolysis; POSTTRAUMATIC-STRESS-DISORDER; ADVERSE DRUG-REACTIONS; CRITICAL-CARE; SURVIVORS; COMPLICATIONS; COMORBIDITY; EXPERIENCES; VALIDATION; PTSD;

D O I：

10.1111/1346-8138.16487

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening adverse reactions to drugs and psychological sequelae are also observed to follow the trauma of widespread epidermal necrolysis. To delineate the association between SJS and TEN, and psychiatric disorders, we conducted a retrospective population-based cohort study by including 212 patients diagnosed with first-time SJS or TEN in Taiwan between 2000 and 2013 and 669 population controls. Adjusted hazard ratios were calculated after adjusting for sex, age, comorbidity in the form of Charlson comorbidity index, and facility level of care. Overall, SJS or TEN was associated with an increased risk of developing psychiatric disorders including schizophrenia, major depressive disorder, mania, anxiety, and bipolar with an adjusted hazard ratio of 1.392 (95% CI, 1.192-1.625; p < 0.001). Particularly, the adjusted hazard ratios of psychiatric disorders were 1.290 (95% CI, 1.105-1.506; p < 0.001) for SJS and 1.855 (95% CI, 1.587-2.167; p < 0.001) for TEN.

引用

页码：979 / 987

页数：9

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