3-Substituted Isocoumarins as Thymidine Phosphorylase Inhibitors

被引：5

作者：

Khan, Khalid Mohammed ^{[1
]}

Ahmed, Sumbul ^{[1
]}

Hussain, Sajjad ^{[1
]}

Ambreen, Nida ^{[1
]}

Perveen, Shahnaz ^{[2
]}

Choudhary, M. Iqbal ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

[2] PCSIR Labs Complex, Karachi 75280, Pakistan

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 04期

关键词：

SCHIFF-BASES; ANTIBACTERIAL; ANGIOGENESIS;

D O I：

10.2174/157018010790945805

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Substituted isocoumarins 1-19 were synthesized and evaluated for their thymidine phosphorylase inhibitory activity. Eight (8) compounds exhibited a varying degree of inhibitory activity towards thymidine phosphorylase from E. coli with IC(50) values between 61-402 mu M. The activities were compared with the standard 7-deazaxanthine (IC(50) = 39.28 +/- 0.76 mu M).

引用

页码：265 / 268

页数：4

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