Oligonucleotide functionalized Fabry-Perot interferometric probe for DNA sequence detection

被引：0

作者：

Wang, Xingwei ^{[1
,2
]}

Xu, Juncheng ^{[1
]}

Wang, Zhuang ^{[1
]}

Cooper, Kristie L. ^{[1
]}

Wang, Anbo ^{[1
]}

Cao, Chengdong ^{[3
]}

机构：

[1] Univ Massachusetts, Dept Elect & Comp Engn, Lowell, MA 01854 USA

[2] Univ Massachusetts Lowell, Elect & Comp Engn Dept, Lowell, MA 01854 USA

[3] Water Saving Off, Nanyang 473000, Peoples R China

来源：

GENETICALLY ENGINEERED AND OPTICAL PROBES FOR BIOMEDICAL APPLICATIONS IV | 2007年 / 6449卷

关键词：

fiber optic sensors; Fabry-Perot; DNA sequence detection;

D O I：

10.1117/12.697431

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper presents a novel fiber optic Fabry-Perot (FP) structure for direct detection of deoxyribonucleic acid (DNA) sequences. The capture DNA is immobilized onto the surface of a silica optical fiber tip by means of the layer-by-layer electrostatic self-assembly (L-b-L ESA) technique. With the FP cavity inside the fiber, the change in optical path length difference (OPD) caused by the immobilization and hybridization can be demodulated. Experimental results demonstrate short (similar to 5 min) response time. In addition, the sensor fabrication is simple and low cost. The signal is stable with high visibility.

引用

页数：8

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