Oligonucleotide functionalized Fabry-Perot interferometric probe for DNA sequence detection

被引：0
作者：
Wang, Xingwei [1 ,2 ]
Xu, Juncheng [1 ]
Wang, Zhuang [1 ]
Cooper, Kristie L. [1 ]
Wang, Anbo [1 ]
Cao, Chengdong [3 ]
机构：
[1] Univ Massachusetts, Dept Elect & Comp Engn, Lowell, MA 01854 USA
[2] Univ Massachusetts Lowell, Elect & Comp Engn Dept, Lowell, MA 01854 USA
[3] Water Saving Off, Nanyang 473000, Peoples R China
来源：
GENETICALLY ENGINEERED AND OPTICAL PROBES FOR BIOMEDICAL APPLICATIONS IV | 2007年 / 6449卷
关键词：
fiber optic sensors; Fabry-Perot; DNA sequence detection;
D O I：
10.1117/12.697431
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
This paper presents a novel fiber optic Fabry-Perot (FP) structure for direct detection of deoxyribonucleic acid (DNA) sequences. The capture DNA is immobilized onto the surface of a silica optical fiber tip by means of the layer-by-layer electrostatic self-assembly (L-b-L ESA) technique. With the FP cavity inside the fiber, the change in optical path length difference (OPD) caused by the immobilization and hybridization can be demodulated. Experimental results demonstrate short (similar to 5 min) response time. In addition, the sensor fabrication is simple and low cost. The signal is stable with high visibility.
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页数：8
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