Trisomy 10 in leukemia

Previous studies had raised questions about whether the relatively rare finding of trisomy 10 in leukemia is nonrandomly associated with a specific immunophenotype or ethnic origin. To shed light on the above questions, and to obtain additional clinical and pathologic information on this unique class of leukemic patients, we conducted a retrospective study of leukemia cases at our laboratory from July 1, 1990, to July 31, 1996. The results not only support the rarity of trisomy 10, but they also reject the hypotheses that all trisomy 10 cases are CD7-positive, or found in Orientals. (C) Elsevier Science Inc., 1998.