Radiotherapy in patients with connective tissue diseases

被引：41

作者：

Giaj-Levra, Niccolo ^{[1
]}

Sciascia, Savino ^{[2
]}

Fiorentino, Alba ^{[1
]}

Fersino, Sergio ^{[1
]}

Mazzola, Rosario ^{[1
]}

Ricchetti, Francesco ^{[1
]}

Roccatello, Dario ^{[2
]}

Alongi, Filippo ^{[1
]}

机构：

[1] Sacro Cuore Hosp, Dept Radiat Oncol, I-37024 Negrar Verona, Italy

[2] Univ Turin, Dept Clin & Biol Sci, Ctr Res Immunopathol & Rare Dis, Coordinating Ctr Piemonte & Valle dAosta Network, Turin, Italy

来源：

LANCET ONCOLOGY | 2016年 / 17卷 / 03期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; INTENSITY-MODULATED RADIOTHERAPY; COLLAGEN VASCULAR-DISEASES; RADIATION-THERAPY; IONIZING-RADIATION; NASOPHARYNGEAL CARCINOMA; CHRONIC TOXICITY; CANCER; SCLERODERMA; SCLEROSIS;

D O I：

10.1016/S1470-2045(15)00417-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The decision to off er radiotherapy in patients with connective tissue diseases continues to be challenging. Radiotherapy might trigger the onset of connective tissue diseases by increasing the expression of self-antigens, diminishing regulatory T-cell activity, and activating effectors of innate immunity (dendritic cells) through Toll-like receptor-dependent mechanisms, all of which could potentially lead to breaks of immune tolerance. This potential risk has raised some debate among radiation oncologists about whether patients with connective tissue diseases can tolerate radiation as well as people without connective tissue diseases. Because the number of patients with cancer and connective tissue diseases needing radiotherapy will probably increase due to improvements in medical treatment and longer life expectancy, the issue of interactions between radiotherapy and connective tissue diseases needs to be clearer. In this Review, we discuss available data and evidence for patients with connective tissue diseases treated with radiotherapy.

引用

页码：E109 / E117

页数：9

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