Neuro-cognitive system dysfunction and symptom sets: A review of fMRI studies in youth with conduct problems

被引：90
作者：
Blair, R. J. R. [1 ]
Veroude, K. [2 ]
Buitelaar, J. K. [2 ,3 ]
机构：
[1] NIMH, Sect Affect Cognit Neurosci, Dept Hlth & Human Serv, NIH, Bldg 15K,Room 206, Bethesda, MD 20892 USA
[2] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Nijmegen, Netherlands
[3] Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands
来源：
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2018年 / 91卷
基金：
美国国家卫生研究院;
关键词：
Conduct disorder; Callous unemotional traits; Empathy; Decision-making; Aggression; CALLOUS-UNEMOTIONAL TRAITS; DISRUPTIVE BEHAVIOR DISORDERS; DEFAULT-MODE NETWORK; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; VENTROMEDIAL PREFRONTAL CORTEX; DEFICIT HYPERACTIVITY DISORDER; OPPOSITIONAL DEFIANT DISORDER; WHITE-MATTER ABNORMALITIES; INFERIOR FRONTAL-CORTEX; PSYCHOPATHIC TRAITS;
D O I：
10.1016/j.neubiorev.2016.10.022
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
In this paper, we review fMRI work on neuro-cognitive systems that are considered to be dysfunctional in individuals with conduct problems (i.e., individuals with Conduct Disorder (CD), Oppositional Defiant Disorder (ODD) or antisocial behavior without formal clinical diagnosis). These are: empathy, the acute threat response, reinforcement-based decision-making, response inhibition and the Default Mode Network. Evidence regarding the Default Mode Network is somewhat inconsistent and its functional role/the symptom sets consequent on its dysfunction remain underspecified. However, dysfunctions in the other four neuro-cognitive systems are associated with symptom sets seen in individuals with conduct problems. Published by Elsevier Ltd.
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收藏
页码：69 / 90
页数：22
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