A retrospective analysis of plasma D-dimer dynamic variation in terminal stage cancer patients: implications for disease progression

被引:2
作者
Zhang, Xi [1 ]
Liu, Zhu-Qing [1 ]
Zhang, Wei [2 ]
Xu, Qing [1 ]
机构
[1] Tongji Univ, Shanghai Peoples Hosp 10, Dept Med Oncol, Shanghai 200072, Peoples R China
[2] Tongji Univ, Shanghai Peoples Hosp 10, Dept Pathol, Sch Med, Shanghai 200072, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2014年 / 7卷 / 08期
基金
中国国家自然科学基金;
关键词
D-dimer; dynamic variation; terminal stage; cancer; disease progression; EPITHELIAL OVARIAN-CANCER; PROGNOSTIC-SIGNIFICANCE; LUNG-CANCER; COAGULATION ASSAYS; COLORECTAL-CANCER; POOR-PROGNOSIS; THROMBOSIS; CARCINOMA;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Elevated D-dimer is frequently found among cancer patients especially for advanced stage patients. Activation of the coagulation system and the fibrinolytic cascade are supposed to be associated with higher risk of invasion, metastases and worse outcome. The purpose of this study is to investigate the dynamic variation of plasma D-dimer and its relationship with other markers of the coagulation system including platelet counts, fibrinogen levels, prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) in terminal stage cancer patients. We designed a self-controlled study to compare plasma D-dimer dynamic variation from 0-4 weeks to 4-8 weeks before patients' death. The plasma D-dimer levels pointed an elevated tendency and revealed statistically significant difference as patients gradually near death. Prolonged PT, APTT and TT were found. D-dimer levels were positively correlated with PT, APTT and TT but showed negative correlation with platelet counts and fibrinogen levels. Plasma D-dimer levels gradually increased as terminal stage cancer patients approaching to death. Increasing D-dimer levels may predict worse outcome.
引用
收藏
页码:2395 / 2401
页数:7
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