Applications of Circulating Tumor Cells and Circulating Tumor DNA in Precision Oncology for Breast Cancers

被引：29

作者：

Addanki, Sridevi ^{[1
,2
]}

Meas, Salyna ^{[2
,3
]}

Sarli, Vanessa Nicole ^{[2
,3
]}

Singh, Balraj ^{[2
,3
]}

Lucci, Anthony ^{[2
,3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Morgan Welch Inflammatory Breast Canc Res Program, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Breast Surg Oncol, Houston, TX 77030 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 14期

关键词：

liquid biopsy; early stage breast cancer; late-stage breast cancer; circulating tumor cells; circulating tumor DNA; next generation sequencing; diagnosis; screening; NEOADJUVANT CHEMOTHERAPY; NONINVASIVE DETECTION; LIQUID BIOPSIES; POOLED ANALYSIS; THERAPY; PLASMA; BLOOD; MULTICENTER; RESISTANCE; SURVIVAL;

D O I：

10.3390/ijms23147843

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liquid biopsies allow for the detection of cancer biomarkers such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). Elevated levels of these biomarkers during cancer treatment could potentially serve as indicators of cancer progression and shed light on the mechanisms of metastasis and therapy resistance. Thus, liquid biopsies serve as tools for cancer detection and monitoring through a simple, non-invasive blood draw, allowing multiple longitudinal sampling. These circulating markers have significant prospects for use in assessing patients' prognosis, monitoring response to therapy, and developing precision medicine. In addition, single-cell omics of these liquid biopsy markers can be potential tools for identifying tumor heterogeneity and plasticity as well as novel therapeutic targets. In this review, we focus on our current understanding of circulating tumor biomarkers, especially in breast cancer, and the scope of novel sequencing technologies and diagnostic methods for better prognostication and patient stratification to improve patient outcomes.

引用

页数：23

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