Sleep and neurochemical modulation by the nuclear peroxisome proliferator-activated receptor α (PPAR-α) in rat

被引：19
|
作者：
Mijangos-Moreno, Stephanie [1 ]
Poot-Ake, Alwin [1 ]
Guzman, Khalil [2 ]
Arankowsky-Sandoval, Gloria [3 ]
Arias-Carrion, Oscar [4 ]
Zaldivar-Rae, Jaime [5 ,6 ,7 ]
Sarro-Ramirez, Andrea [1 ]
Murillo-Rodriguez, Eric [1 ,6 ,7 ]
机构：
[1] Univ Anahuac Mayab, Lab Neurociencias Mol & Integrat, Div Ciencias Salud, Escuela Med, Carretera Merida Progreso Km 15-5,AP 96 Cordemex, Merida 97310, Yucatan, Mexico
[2] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Neuropatol Mol, Mexico City 04510, DF, Mexico
[3] Univ Autonoma Yucatan, Ctr Invest Reg Dr Hideyo Noguchi, Merida, Yucatan, Mexico
[4] Hosp Gen Dr Manuel Gea Gonzalez, Unidad Trastornos Movimiento & Sueno TMS, Mexico City, DF, Mexico
[5] Univ Anahuac Mayab, Coordinac Invest, Vicerrectoria Acad, Merida 97310, Yucatan, Mexico
[6] Univ Anahuac Mayab, Div Ciencias Salud, Grp Invest Envejecimiento, Merida 97310, Yucatan, Mexico
[7] Univ Anahuac Mayab, Div Ingn & Ciencias Exactas, Grp Invest Desarrollos Tecnol Salud, Merida 97310, Yucatan, Mexico
来源：
NEUROSCIENCE RESEARCH | 2016年 / 105卷
关键词：
Microdialysis; Dopamine; Adenosine; Waking; Serotonin; HPLC; WAKE REGULATION; ADENOSINE; DOPAMINE; MICE; MICRODIALYSIS; EXPRESSION; FOREBRAIN; INHIBITOR; ACCUMBENS; NICOTINE;
D O I：
10.1016/j.neures.2015.09.005
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The peroxisome proliferator-activated receptor alpha (PPAR alpha) is a nuclear protein that plays an essential role in diverse neurobiological processes. However, the role of PPAR alpha on the sleep modulation is unknown. Here, rats treated with an intrahypothalamic injection of Wy14643 (10 mu g/1 mu L ; PPAR alpha agonist) enhanced wakefulness and decreased slow wave sleep and rapid eye movement sleep whereas MK-886 (10 mu g/1 mu L; PPAR alpha antagonist) promoted opposite effects. Moreover, Wy14643 increased dopamine, norepinephrine, serotonin, and adenosine contents collected from nucleus accumbens. The levels of these neurochemicals were diminished after MK-886 treatment. The current findings suggest that PPAR alpha may participate in the sleep and neurochemical modulation. (C) 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
引用
收藏
页码：65 / 69
页数：5
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