High-Fat Diet-Induced Met-Hemoglobin Formation in Rats Prone (WOKW) or Resistant (DA) to the Metabolic Syndrome: Effect of CoQ10 Supplementation

被引：10

作者：

Orlando, Patrick ^{[1
]}

Silvestri, Sonia ^{[1
]}

Bruge, Francesca ^{[1
]}

Tiano, Luca ^{[1
]}

Kloting, Ingrid ^{[2
]}

Falcioni, Giancarlo ^{[3
]}

Polidori, Carlo ^{[3
]}

机构：

[1] Polytech Univ Marche, Dept Clin & Dent Sci, I-60131 Ancona, AN, Italy

[2] Ernst Moritz Arndt Univ Greifswald, Dept Lab Anim Sci, Karlsburg, Germany

[3] Univ Camerino, Sch Pharm & Hlth Prod, I-62032 Camerino, Italy

来源：

BIOFACTORS | 2014年 / 40卷 / 06期

关键词：

WistarOttawaKarlsburg W; Dark Agouti; coenzyme Q(10); hemoglobin; methemoglobin; oxidative stress; high-fat diet; metabolic syndrome; OXIDATIVE STRESS; COENZYME-Q; INSULIN-RESISTANCE; ANTIOXIDANT STATUS; ALPHA-TOCOPHEROL; GENERATION; ADIPOSITY; CELLS; YOUNG; Q(10);

D O I：

10.1002/biof.1190

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to evaluate the effects of a high-fat diet (HFD) on oxidative indexes in WistarOttawaKarlsburg W (WOKW) rats used as a model of metabolic syndrome in comparison with Dark Agouti (DA) rats used as a control strain. This syndrome is defined by the occurrence of two or more risk factors including obesity, hypertension, dyslipidemia, and insulin resistance. Forty rats were used in the study and the effect of HFD was evaluated in terms of body weight and both hemoglobin and CoQ oxidative status. Moreover, 16 rats (8 of each strain) were supplemented with 3 mg/100 g b.w. of CoQ(10) for 1 month in view of its beneficial properties in cardiovascular disease due to its antioxidant activity in the lipid environment. HFD promoted an increase in body weight, in particular in WOKW males, and in the methemoglobin (met-Hb) index in both strains. Moreover, HFD promoted endogenous CoQ(10) oxidation. CoQ(10) supplementation was able to efficiently counteract the HFD pro-oxidant effects, preventing met-Hb formation and CoQ oxidation. (c) 2014 BioFactors, 40(6):603-609, 2014

引用

页码：603 / 609

页数：7

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