Toll-like receptor 9 ligand blocks osteoclast differentiation through induction of phosphatase

被引：21

作者：

Amcheslavsky, Alla ^{[1
]}

Bar-Shavit, Zvi ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hubert H Humphrey Ctr Expt Med & Canc Res, Fac Med, IL-91120 Jerusalem, Israel

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 08期

关键词：

Toll-like receptors; CpG-oligodeoxynucleotides; extracellular signal-related kinase; c-fos; osteoclasts;

D O I：

10.1359/JBMR.070501

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CpG-ODN, in addition to stimulation of osteoclastogenic signals in early osteoclast precursors, also induces phosphatase, shifting the pattern of ERK phosphorylation from sustained to transient. This shift results in the degradation of c-fos, an essential molecule for osteoclast differentiation. Therefore, CpG-ODN blocks osteoclast differentiation.

引用

页码：1301 / 1310

页数：10

共 67 条

[61] Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity [J].