Toll-like receptor 9 ligand blocks osteoclast differentiation through induction of phosphatase

被引：21
作者：
Amcheslavsky, Alla [1 ]
Bar-Shavit, Zvi [1 ]
机构：
[1] Hebrew Univ Jerusalem, Hubert H Humphrey Ctr Expt Med & Canc Res, Fac Med, IL-91120 Jerusalem, Israel
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 08期
关键词：
Toll-like receptors; CpG-oligodeoxynucleotides; extracellular signal-related kinase; c-fos; osteoclasts;
D O I：
10.1359/JBMR.070501
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
CpG-ODN, in addition to stimulation of osteoclastogenic signals in early osteoclast precursors, also induces phosphatase, shifting the pattern of ERK phosphorylation from sustained to transient. This shift results in the degradation of c-fos, an essential molecule for osteoclast differentiation. Therefore, CpG-ODN blocks osteoclast differentiation.
引用
收藏
页码：1301 / 1310
页数：10
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