Toll-like receptor 9 ligand blocks osteoclast differentiation through induction of phosphatase

被引：21

作者：

Amcheslavsky, Alla ^{[1
]}

Bar-Shavit, Zvi ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hubert H Humphrey Ctr Expt Med & Canc Res, Fac Med, IL-91120 Jerusalem, Israel

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 08期

关键词：

Toll-like receptors; CpG-oligodeoxynucleotides; extracellular signal-related kinase; c-fos; osteoclasts;

D O I：

10.1359/JBMR.070501

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CpG-ODN, in addition to stimulation of osteoclastogenic signals in early osteoclast precursors, also induces phosphatase, shifting the pattern of ERK phosphorylation from sustained to transient. This shift results in the degradation of c-fos, an essential molecule for osteoclast differentiation. Therefore, CpG-ODN blocks osteoclast differentiation.

引用

页码：1301 / 1310

页数：10

共 67 条

[1] Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor [J].

AbuAmer, Y ;

Ross, FP ;

Edwards, J ;

Teitelbaum, SL .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (06) :1557-1565

[2] Toll-like receptors: critical proteins linking innate and acquired immunity [J].

Akira, S ;

Takeda, K ;

Kaisho, T .

NATURE IMMUNOLOGY, 2001, 2 (08) :675-680

[3] INACTIVATION OF P42 MAP KINASE BY PROTEIN PHOSPHATASE 2A AND A PROTEIN-TYROSINE-PHOSPHATASE, BUT NOT CL100, IN VARIOUS CELL-LINES [J].

ALESSI, DR ;

GOMEZ, N ;

MOORHEAD, C ;

LEWIS, T ;

KEYSE, SM ;

COHEN, P .

CURRENT BIOLOGY, 1995, 5 (03) :283-295

[4] Differential contribution of osteoclast- and osteoblast-lineage cells to CpG-oligodeoxynucleotide (CpG-ODN) modulation of osteoclastogenesis [J].

Amcheslavsky, A ;

Hemmi, H ;

Akira, S ;

Bar-Shavit, Z .

JOURNAL OF BONE AND MINERAL RESEARCH, 2005, 20 (09) :1692-1699

[5] Toll-like receptor 9 regulates tumor necrosis factor-α expression by different mechanisms -: Implications for osteoclastogenesis [J].

Amcheslavsky, A ;

Zou, W ;

Bar-Shavit, Z .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (52) :54039-54045

[6] Interleukin (IL)-12 mediates the anti-osteoclastogenic activity of CpG-oligodeoxynucleotides [J].

Amcheslavsky, A ;

Bar-Shavit, Z .

JOURNAL OF CELLULAR PHYSIOLOGY, 2006, 207 (01) :244-250

[7] MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network [J].

Bhalla, US ;

Ram, PT ;

Iyengar, R .

SCIENCE, 2002, 297 (5583) :1018-1023

[8] INHIBITORY EFFECT OF A MARINE-SPONGE TOXIN, OKADAIC ACID, ON PROTEIN PHOSPHATASES - SPECIFICITY AND KINETICS [J].

BIALOJAN, C ;

TAKAI, A .

BIOCHEMICAL JOURNAL, 1988, 256 (01) :283-290

[9] Interferon α and CPG oligodeoxynucleotides elicit additive immunostimulatory and antitumor effects [J].

Brown, Lloyd ;

Roda, Julie ;

Terrell, Catherine ;

Chaudhury, Abhik Ray ;

Crespin, Tim ;

Carson, William E. ;

Lesinski, Gregory B. .

SURGERY, 2006, 140 (02) :297-306

[10] Dual specificity phosphatases: a gene family for control of MAP kinase function [J].

Camps, M ;

Nichols, A ;

Arkinstall, S .

FASEB JOURNAL, 2000, 14 (01) :6-16

← 1 2 3 4 5 6 7 →