Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu

被引：192

作者：

Zhou, Xiaohui ^{[1
,2
]}

Kong, Ning ^{[1
,3
]}

Wang, Julie ^{[1
]}

Fan, Huiming ^{[2
]}

Zou, Hejian ^{[3
]}

Horwitz, David ^{[1
,4
]}

Brand, David

Liu, Zhongmin ^{[2
]}

Zheng, Song Guo ^{[1
]}

机构：

[1] Univ So Calif, Div Rheumatol, Los Angeles, CA 90033 USA

[2] Tongji Univ, Shanghai E Hosp, Immune Tolerance Ctr, Shanghai 200120, Peoples R China

[3] Fudan Univ, Huashan Hosp, Shanghai 200433, Peoples R China

[4] Vet Affairs Med Ctr, Res Serv, Memphis, TN 38104 USA

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 05期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

TGF-BETA; ADOPTIVE TRANSFER; TH17; CELLS; SUPPRESSION; INDUCTION; MICE; IL-2; SELF;

D O I：

10.4049/jimmunol.1000598

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have demonstrated that plasticity of naturally occurring CD4(+)Foxp3(+) regulatory T cells (nTregs) may account for their inability to control chronic inflammation in established autoimmune diseases. All-trans retinoic acid (atRA), the active derivative of vitamin A, has been demonstrated to promote Foxp3(+) Treg differentiation and suppress Th17 development. In this study, we report a vital role of atRA in sustaining the stability and functionality of nTregs in the presence of IL-6. We found that nTregs treated with atRA were resistant to Th17 and other Th cell conversion and maintained Foxp3 expression and suppressive activity in the presence of IL-6 in vitro. atRA decreased IL-6R expression and signaling by nTregs. Of interest, adoptive transfer of nTregs even from arthritic mice treated with atRA suppressed progression of established collagen-induced arthritis. We suggest that nTregs treated with atRA may represent a novel treatment strategy to control established chronic immune-mediated inflammatory diseases. The Journal of Immunology, 2010, 185: 2675-2679.

引用

页码：2675 / 2679

页数：5

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