Energy and electron transfer processes in flavoprotein-mediated DNA repair

被引：27

作者：

Heelis, PF ^{[1
]}

Hartman, RF ^{[1
]}

Rose, SD ^{[1
]}

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM & BIOCHEM,TEMPE,AZ 85287

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 1996年 / 95卷 / 01期

关键词：

energy transfer; electron transfer; flavoprotein-mediated DNA repair;

D O I：

10.1016/1010-6030(95)04229-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The flavin photoenzyme, DNA photolyase, utilizes a photon to repair the main damage to DNA (pyrimidine dimers) caused by UV light. DNA photolyases are monomeric flavoproteins that bind to the cis-syn-pyrimidine dimer in DNA in a light-independent step, forming a stable enzyme-substrate complex. This complex absorbs a photon, leading to electron transfer to the pyrimidine dimer, producing an unstable cyclobutane radical anion and thereby initiating bond cleavage in the dimer. The mechanism and energetics involved in the action of this remarkable enzyme are reviewed.

引用

页码：89 / 98

页数：10

共 21 条

[1] PHOTOREACTIVATION IN HUMANS [J].