miR-22 as a prognostic factor targets glucose transporter protein type 1 in breast cancer

被引：88

作者：

Chen, Bo ^{[1
,2
]}

Tang, Hailin ^{[1
,2
]}

Liu, Xiaoping ^{[1
,2
]}

Liu, Peng ^{[1
,2
]}

Yang, Lu ^{[1
,2
]}

Xie, Xinhua ^{[1
,2
]}

Ye, Feng ^{[1
,2
]}

Song, Cailu ^{[1
,2
]}

Xie, Xiaoming ^{[1
,2
]}

Wei, Weidong ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Ctr Canc, Dept Breast Oncol, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510275, Guangdong, Peoples R China

来源：

CANCER LETTERS | 2015年 / 356卷 / 02期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

miR-22; GLUT1; Breast cancer; Prognostic factor; GASTRIC-CANCER; EXPRESSION; PROGRESSION; PROLIFERATION; TRANSCRIPTION; MICRORNA-22; INVASION;

D O I：

10.1016/j.canlet.2014.09.028

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It has been reported that miR-22 plays an important role and may be a promising therapeutic target in cancer. In this study, we found that GLUT1 is a direct target of miR-22. The ectopic expression of miR-22 inhibited breast cancer cell proliferation and invasion by targeting GLUT1. A reverse correlation between the expression of miR-22 and GLUT1 was observed in breast cancer tissue samples. Furthermore, miR-22 was significantly correlated with the TNM stage, local relapse, distant metastasis, and survival of breast cancer patients. Our data suggest that miR-22 functions as a tumor suppressor and is a promising prognostic biomarker in breast cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：410 / 417

页数：8

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