Retinal nerve fibre layer thickness is reduced in metabolic syndrome

AimsTo investigate retinal nerve fibre layer (RNFL) thickness in people with metabolic syndrome (MetS) and healthy controls. MethodsA cross-sectional study was performed from March 2014 to January 2016. All participants underwent anthropometric and serological biochemical measurements, ophthalmological examination, and spectral-domain optical coherence tomography (SD-OCT). Individuals with elevated intraocular pressure, glaucoma, diabetic retinopathy and other ocular disorders were excluded. T-test, Chi square and general linear modelswere used to analyse the data. ResultsIn total, 278 eyes from 139 participants were investigated [median (interquartile range) age: 37 (32-43)years]. RNFL thickness was lower in the nasal superior (107.819.5m) and temporal superior (135.718.9m) sectors in MetS group compared with the control group (114.622.4m, P=0.013 and 140.718.2m, P=0.027, respectively). After multiple adjustments for age, gender and the side of the examined [right (OD)/left (OS)] eye, MetS was independently associated with a lower RFNL thickness in the nasal superior (=0.20, P=0.009) and temporal superior (=0.14, P=0.048) sectors. RNFL thickness was significantly reduced in participants with higher numbers of metabolic abnormalities, independent of age, gender and the side of the examined eye (P=0.043). ConclusionOur findings demonstrate that MetS is independently associated with reduced RNFL thickness, suggesting that neurodegeneration is implicated in pathogenesis of MetS.