Imetelstat inhibits growth of megakaryocyte colony-forming units from patients with essential thrombocythemia

被引：11

作者：

Baerlocher, Gabriela M. ^{[1
,2
,3
]}

Haubitz, Monika ^{[3
]}

Braschler, Thomas R. ^{[1
,2
,4
]}

Brunold, Claudio ^{[1
,2
]}

Burington, Bart ^{[5
]}

Leibundgut, Elisabeth Oppliger ^{[1
,2
,3
]}

Go, Ning ^{[5
]}

机构：

[1] Univ Bern, Bern Univ Hosp, Inselspital, Dept Hematol, Bern, Switzerland

[2] Univ Bern, Bern Univ Hosp, Inselspital, Cent Hematol Lab, Bern, Switzerland

[3] Univ Bern, Dept BioMed Res, Lab Hematopoiesis & Mol Genet, Bern, Switzerland

[4] Luzerner Kantonsspital, Dept Hematol, Luzern, Switzerland

[5] Geron Corp, Menlo Pk, CA USA

来源：

BLOOD ADVANCES | 2019年 / 3卷 / 22期

关键词：

TELOMERASE INHIBITOR; GRN163; HTERT;

D O I：

10.1182/bloodadvances.2019000167

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：3724 / 3728

页数：5

共 16 条

[1]

Asai A, 2003, CANCER RES, V63, P3931

[2] Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia [J].

Baerlocher, Gabriela M. ;

Leibundgut, Elisabeth Oppliger ;

Ottmann, Oliver G. ;

Spitzer, Gary ;

Odenike, Olatoyosi ;

McDevitt, Michael A. ;

Roth, Alexander ;

Daskalakis, Michael ;

Burington, Bart ;

Stuart, Monic ;

Snyder, David S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (10) :920-928

[3] Response criteria for essential thrombocythemia and polycythemia vera: result of a European LeukemiaNet consensus conference [J].

Barosi, Giovanni ;

Birgegard, Gunnar ;

Finazzi, Guido ;

Griesshammer, Martin ;

Harrison, Claire ;

Hasselbalch, Hans Carl ;

Kiladjian, Jean-Jacques ;

Lengfelder, Eva ;

McMullin, Mary Frances ;

Passamonti, Francesco ;

Reilly, John T. ;

Vannucchi, Alessandro M. ;

Barbui, Tiziano .

BLOOD, 2009, 113 (20) :4829-4833

[4] Different expression levels of the telomerase catalytic subunit hTERT in myeloproliferative and myelodysplastic diseases [J].

Bock, O ;

Serinsöz, E ;

Schlué, J ;

Kreipe, H .

LEUKEMIA RESEARCH, 2004, 28 (05) :457-460

[5] Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes [J].

Dong, Wen ;

Qian, Yaqin ;

Yang, Lili .

LEUKEMIA RESEARCH, 2014, 38 (07) :830-835

[6]

Fenaux P, 2019, HEMASPHERE, V3, P372

[7] Different immunophenotypical apoptotic profiles characterise megakaryocytes of essential thrombocythaemia and primary myelofibrosis [J].

Florena, A. M. ;

Tripodo, C. ;

Di Bernardo, A. ;

Iannitto, E. ;

Guarnotta, C. ;

Porcasi, R. ;

Ingrao, S. ;

Abbadessa, V. ;

Franco, V. .

JOURNAL OF CLINICAL PATHOLOGY, 2009, 62 (04) :331-338

[8] Lipid modification of GRN163, an N3′ → P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition [J].

Herbert, BS ;

Gellert, GC ;

Hochreiter, A ;

Pongracz, K ;

Wright, WE ;

Zielinska, D ;

Chin, AC ;

Harley, CB ;

Shay, JW ;

Gryaznov, SM .

ONCOGENE, 2005, 24 (33) :5262-5268

[9] SPECIFIC ASSOCIATION OF HUMAN TELOMERASE ACTIVITY WITH IMMORTAL CELLS AND CANCER [J].

KIM, NW ;

PIATYSZEK, MA ;

PROWSE, KR ;

HARLEY, CB ;

WEST, MD ;

HO, PLC ;

COVIELLO, GM ;

WRIGHT, WE ;

WEINRICH, SL ;

SHAY, JW .

SCIENCE, 1994, 266 (5193) :2011-2015

[10] Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP) [J].

Kim, NW ;

Wu, F .

NUCLEIC ACIDS RESEARCH, 1997, 25 (13) :2595-2597

← 1 2 →