Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

被引：53

作者：

Tsai, An-Chi ^{[1
]}

Pan, Shiow-Lin ^{[1
,4
]}

Liao, Cho-Hwa ^{[1
]}

Guh, Jih-Hwa ^{[2
]}

Wang, Shih-Wei ^{[1
]}

Sun, Hui-Lung ^{[1
]}

Liu, Yi-Nan ^{[1
]}

Chen, Chien-Chih ^{[3
]}

Shen, Chien-Chang ^{[3
]}

Chang, Ya-Ling ^{[1
]}

Teng, Che-Ming ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan

[2] Natl Taiwan Univ, Sch Med, Coll Med, Taipei, Taiwan

[3] Natl Res Inst Chinese Med, Taipei, Taiwan

[4] Taipei Med Univ, Grad Inst Pharmacol, Taipei, Taiwan

来源：

CANCER LETTERS | 2010年 / 292卷 / 02期

关键词：

Moscatilin; VEGF; bFGF; Endothelial cells; Angiogenesis; NITRIC-OXIDE SYNTHASE; P42/P44 MAP KINASE; ENDOTHELIAL-CELLS; SIGNALING ANGIOGENESIS; AKT; PHOSPHORYLATION; INHIBITION; CANCER; NEOVASCULARIZATION; TRANSDUCTION;

D O I：

10.1016/j.canlet.2009.11.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy (C) 2009 Elsevier Ireland Ltd All rights reserved

引用

页码：163 / 170

页数：8

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