Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

被引：53

作者：

Tsai, An-Chi ^{[1
]}

Pan, Shiow-Lin ^{[1
,4
]}

Liao, Cho-Hwa ^{[1
]}

Guh, Jih-Hwa ^{[2
]}

Wang, Shih-Wei ^{[1
]}

Sun, Hui-Lung ^{[1
]}

Liu, Yi-Nan ^{[1
]}

Chen, Chien-Chih ^{[3
]}

Shen, Chien-Chang ^{[3
]}

Chang, Ya-Ling ^{[1
]}

Teng, Che-Ming ^{[1
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan

[2] Natl Taiwan Univ, Sch Med, Coll Med, Taipei, Taiwan

[3] Natl Res Inst Chinese Med, Taipei, Taiwan

[4] Taipei Med Univ, Grad Inst Pharmacol, Taipei, Taiwan

来源：

CANCER LETTERS | 2010年 / 292卷 / 02期

关键词：

Moscatilin; VEGF; bFGF; Endothelial cells; Angiogenesis; NITRIC-OXIDE SYNTHASE; P42/P44 MAP KINASE; ENDOTHELIAL-CELLS; SIGNALING ANGIOGENESIS; AKT; PHOSPHORYLATION; INHIBITION; CANCER; NEOVASCULARIZATION; TRANSDUCTION;

D O I：

10.1016/j.canlet.2009.11.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy (C) 2009 Elsevier Ireland Ltd All rights reserved

引用

页码：163 / 170

页数：8

共 35 条

[1] Blockade of nitric-oxide synthase reduces choroidal neovascularization [J].

Ando, A ;

Yang, A ;

Nambu, H ;

Campochiaro, PA .

MOLECULAR PHARMACOLOGY, 2002, 62 (03) :539-544

[2] Role of nitric oxide in the angiogenic response in vitro to basic fibroblast growth factor [J].

Babaei, S ;

Teichert-Kuliszewska, K ;

Monge, JC ;

Mohamed, F ;

Bendeck, MP ;

Stewart, DJ .

CIRCULATION RESEARCH, 1998, 82 (09) :1007-1015

[3] Signaling angiogenesis via p42/p44 MAP kinase and hypoxia [J].

Berra, E ;

Milanini, J ;

Richard, DE ;

Le Gall, M ;

Viñals, F ;

Gothié, E ;

Roux, D ;

Pagès, G ;

Pouysségur, J .

BIOCHEMICAL PHARMACOLOGY, 2000, 60 (08) :1171-1178

[4] Tumor angiogenesis - A potential target in cancer chemoprevention [J].

Bhat, Tariq A. ;

Singh, Rana P. .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (04) :1334-1345

[5] The phosphoinositide 3-kinase pathway [J].

Cantley, LC .

SCIENCE, 2002, 296 (5573) :1655-1657

[6] ANTIPLATELET AGGREGATION PRINCIPLES OF DENDROBIUM-LODDIGESII [J].

CHEN, CC ;

WU, LG ;

KO, FN ;

TENG, CM .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (09) :1271-1274

[7] Moscatilin induces apoptosis in human colorectal cancer cells:: A crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage [J].

Chen, Tzu-Hsuan ;

Pan, Shiow-Lin ;

Guh, Jih-Hwa ;

Liao, Cho-Hwa ;

Huang, Der-Yi ;

Chen, Chien-Chih ;

Teng, Che-Ming .

CLINICAL CANCER RESEARCH, 2008, 14 (13) :4250-4258

[8] NO and angiogenesis [J].

Cooke, JP .

ATHEROSCLEROSIS SUPPLEMENTS, 2003, 4 (04) :53-60

[9] FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition [J].

Cross, MJ ;

Claesson-Welsh, L .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2001, 22 (04) :201-207

[10] VEGF-receptor signal transduction [J].

Cross, MJ ;

Dixelius, J ;

Matsumoto, T ;

Claesson-Welsh, L .

TRENDS IN BIOCHEMICAL SCIENCES, 2003, 28 (09) :488-494

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