The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae

被引：115

作者：

Berset, C ^{[1
]}

Trachsel, H ^{[1
]}

Altmann, M ^{[1
]}

机构：

[1] Univ Bern, Inst Biochem & Mol Biol, CH-3012 Bern, Switzerland

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 08期

关键词：

cell cycle; starvation; protein degradation;

D O I：

10.1073/pnas.95.8.4264

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Initiation factor eIF4G is an essential protein required for initiation of mRNA translation via the 5' cap-dependent pathway. It interacts with eIF4E (the mRNA 5' cap-binding protein) and serves as an anchor for the assembly of further initiation factors. With treatment of Saccharomyces cerevisiae with rapamycin or with entry of cells into the diauxic phase, eIF4G is rapidly degraded, whereas initiation factors eIF4E and eIF4A remain stable. We propose that nutritional deprivation or interruption of the TOR signal transduction pathway induces eIF4G degradation.

引用

页码：4264 / 4269

页数：6

共 45 条

[1] NUCLEOTIDE-SEQUENCE OF THE GENE ENCODING A 20 KDA PROTEIN ASSOCIATED WITH THE CAP BINDING-PROTEIN ELF-4E FROM SACCHAROMYCES-CEREVISIAE [J].

ALTMANN, M ;

KRIEGER, M ;

TRACHSEL, H .

NUCLEIC ACIDS RESEARCH, 1989, 17 (18) :7520-7520

[2] A novel inhibitor of cap-dependent translation initiation in yeast: P20 competes with eIF4G for binding to eIF4E [J].

Altmann, M ;

Schmitz, N ;

Berset, C ;

Trachsel, H .

EMBO JOURNAL, 1997, 16 (05) :1114-1121

[3] TOR controls translation initiation and early G1 progression in yeast [J].

Barbet, NC ;

Schneider, U ;

Helliwell, SB ;

Stansfield, I ;

Tuite, MF ;

Hall, MN .

MOLECULAR BIOLOGY OF THE CELL, 1996, 7 (01) :25-42

[4] Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation [J].

Beretta, L ;

Gingras, AC ;

Svitkin, YV ;

Hall, MN ;

Sonenberg, N .

EMBO JOURNAL, 1996, 15 (03) :658-664

[5] A signaling pathway to translational control [J].

Brown, EJ ;

Schreiber, SL .

CELL, 1996, 86 (04) :517-520

[6] FKBP12-RAPAMYCIN TARGET TOR2 IS A VACUOLAR PROTEIN WITH AN ASSOCIATED PHOSPHATIDYLINOSITOL-4 KINASE-ACTIVITY [J].

CARDENAS, ME ;

HEITMAN, J .

EMBO JOURNAL, 1995, 14 (23) :5892-5907

[7] REGULATED IMPORT AND DEGRADATION OF A CYTOSOLIC PROTEIN IN THE YEAST VACUOLE [J].

CHIANG, HL ;

SCHEKMAN, R .

NATURE, 1991, 350 (6316) :313-318

[8] RAPT1, A MAMMALIAN HOMOLOG OF YEAST TOR, INTERACTS WITH THE FKBP12 RAPAMYCIN COMPLEX [J].

CHIU, MI ;

KATZ, H ;

BERLIN, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (26) :12574-12578

[9] A NEW YEAST TRANSLATION INITIATION-FACTOR SUPPRESSES A MUTATION IN THE ELF-4A RNA HELICASE [J].

COPPOLECCHIA, R ;

BUSER, P ;

STOTZ, A ;

LINDER, P .

EMBO JOURNAL, 1993, 12 (10) :4005-4011

[10] ISOLATION OF A PROTEIN COMPLEX CONTAINING TRANSLATION INITIATION-FACTOR PRT1 FROM SACCHAROMYCES-CEREVISIAE [J].

DANAIE, P ;

WITTMER, B ;

ALTMANN, M ;

TRACHSEL, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (09) :4288-4292

← 1 2 3 4 5 →