Antiviral and Anti-inflammatory Diterpenoids from the Soft Coral Sinularia gyrosa

被引：36

作者：

Cheng, Shi-Yie ^{[2
,4
,5
]}

Chuang, Cheng-Ta ^{[2
,4
]}

Wang, Shang-Kwei ^{[1
]}

Wen, Zhi-Hong ^{[2
,4
]}

Chiou, Shu-Fen ^{[2
,4
]}

Hsu, Chi-Hsin ^{[2
,4
]}

Dai, Chang-Feng ^{[3
]}

Duh, Chang-Yih ^{[2
,4
,5
]}

机构：

[1] Kaohsiung Med Univ, Dept Microbiol, Kaohsiung, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[3] Natl Taiwan Univ, Inst Oceanog, Taipei 10764, Taiwan

[4] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[5] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 06期

关键词：

ABSOLUTE-CONFIGURATIONS; LOBOPHYTUM; METABOLITES; DERIVATIVES; DILOPHOL; FUSCOL;

D O I：

10.1021/np100185a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of the salt coral Sinularia gyrosa led to the purification of three new diterpenoids. designated as gyrosanols A-C (1-3). The structures of 1-3 were elucidated through extensive spectroscopic analyses. Compounds 1 and 2 exhibited antiviral activity against HCMV with IC(50)'s of 2.6 and 3.7 mu M, respectively. In addition, compounds 1 and 2 showed significant anti-inflammatory activity by reducing the levels of the COX-2 protein (19.6 +/- 3.9% and 29.1 +/- 9.6%, respectively) in RAW 264.7 macrophages.

引用

页码：1184 / 1187

页数：4

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