Langerin functions as an antiviral receptor on Langerhans cells

被引：63
作者：
van der Vlist, Michiel
Geijtenbeek, Teunis B. H. [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Ctr Expt & Mol Med, NL-1105 AZ Amsterdam, Netherlands
来源：
IMMUNOLOGY AND CELL BIOLOGY | 2010年 / 88卷 / 04期
关键词：
C-type lectin; Langerin; HIV-1; transmission; pattern recognition receptor; Langerhans cell; antiviral; HUMAN-IMMUNODEFICIENCY-VIRUS; C-TYPE LECTIN; GRAM-POSITIVE BACTERIA; HUMAN DENDRITIC CELLS; DC-SIGN; T-CELLS; BIRBECK GRANULES; ANTIGEN PRESENTATION; HIV-1; INFECTION; MYCOBACTERIUM-TUBERCULOSIS;
D O I：
10.1038/icb.2010.32
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Langerhans cells (LC) are the first dendritic cells (DC) to encounter pathogens entering the body via mucosa or skin. Equipped with pattern recognition receptors (PRR), LC are able to detect and respond to these pathogens. An important PRR, in human exclusively expressed by LC, is the C-type lectin Langerin. Langerin forms a protective barrier against HIV-1 infection by binding and degradation of this virus. In addition, antigens targeted to Langerin are presented to T cells to induce an adaptive immune response. Therefore Langerin functions as an innate anti-viral defense mechanism and an antigen receptor involved in adaptive immune responses. Here, we review the role of Langerin in antiviral protection, its structural similarity to other C-type lectins, and how its function and polymorphisms influence the function of Langerhans cells. Immunology and Cell Biology (2010) 88, 410-415; doi: 10.1038/icb.2010.32; published online 23 March 2010
引用
收藏
页码：410 / 415
页数：6
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