Crocus Sativus L. (saffron) versus sertraline on symptoms of depression among older people with major depressive disorders-a double-blind, randomized intervention study

被引:34
作者
Ahmadpanah, Mohammad [1 ]
Ramezanshams, Fatemeh [1 ]
Ghaleiha, Ali [1 ]
Akhondzadeh, Shahin [2 ]
Bahmani, Dena Sadeghi [3 ,4 ,5 ,6 ]
Brand, Serge [2 ,3 ,5 ,6 ,7 ]
机构
[1] Hamadan Univ Med Sci, Behav Disorders & Subst Abuse Res Ctr, Hamadan, Iran
[2] Univ Tehran Med Sci, Roozbeh Hosp, Psychiat & Psychol Res Ctr, Dept Psychiat,Sch Med, Tehran, Iran
[3] Univ Basel, Ctr Affect Stress & Sleep Disorders, Psychiat Clin UPK, Basel, Switzerland
[4] Isfahan Univ Med Sci, Isfahan Neurosci Res Ctr, Alzahra Res Inst, Esfahan, Iran
[5] Kermanshah Univ Med Sci, Sleep Disorders Res Ctr, Kermanshah, Iran
[6] Kermanshah Univ Med Sci, Subst Abuse Prevent Res Ctr, Hlth Inst, Kermanshah, Iran
[7] Univ Basel, Dept Sport Exercise & Hlth, Div Sport & Psychosocial Hlth, Basel, Switzerland
关键词
Major depressive disorder; Crocus Sativus L; Sertraline; Older people; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT-RESISTANT DEPRESSION; COGNITIVE-BEHAVIORAL THERAPY; FATTY-ACIDS; ELECTROCONVULSIVE-THERAPY; CONTROLLED-TRIALS; PLACEBO; EFFICACY; EXERCISE; METAANALYSIS;
D O I
10.1016/j.psychres.2019.112613
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: While there is sufficient evidence that Crocus Sativus L. (saffron) improves symptoms of depression in young and middle-aged adults, research on older people are missing. The purpose of the double-blind, randomized intervention study was to compare the effect of saffron and sertraline on MDD among a sample of older people. Methods: A total of 50 older out-patients with MOD (mean age = = 65 years; 70% males) were randomly assigned either to the saffron condition (60 mg/d) or to the sertraline condition (100 mg/day) for six consecutive weeks. Experts employed the Hamilton Depression Rating Scale (HDRS) to rate participants' degree of depression. Timepoints were baseline, week 2, week 4 and week 6, the end of the study. Results: Symptoms of depression decreased over time, with no advantages or disadvantages for the saffron or sertraline condition. Conclusion: The pattern of results suggests that both saffron and sertraline have the potential to significantly decrease symptoms of depression. The results are clinically relevant, because major depressive disorders in older people is a health concern. The results are further relevant, because saffron appears to be a powerful antidepressant for older people, who might be more reluctant to the use of synthetic drugs.
引用
收藏
页数:6
相关论文
共 42 条
[1]  
[Anonymous], 1988, Statistical Power Analysis for the Behavioral Sciences
[2]   A systematic review of St. John's wort for major depressive disorder [J].
Apaydin E.A. ;
Maher A.R. ;
Shanman R. ;
Booth M.S. ;
Miles J.N.V. ;
Sorbero M.E. ;
Hempel S. .
Systematic Reviews, 5 (1)
[3]   Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients:: A pilot double-blind randomized trial [J].
Basti, Afshin Akhondzadeh ;
Moshiri, Esmail ;
Noorbala, Ahamad-Ali ;
Jamshidi, Amir-Hossein ;
Abbasi, Seyed Hesameddin ;
Akhondzadeh, Shahin .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2007, 31 (02) :439-442
[4]  
Boesen K, 2018, LANCET, V392, P1011, DOI 10.1016/S0140-6736(18)31783-5
[5]   Challenging the promotion of antidepressants for nonsevere depression [J].
Braillon, A. ;
Lexchin, J. ;
Noble, J. H. ;
Menkes, D. ;
M'sahli, L. ;
Fierlbeck, K. ;
Blumsohn, A. ;
Naudet, F. .
ACTA PSYCHIATRICA SCANDINAVICA, 2019, 139 (03) :294-295
[6]   The "pharmaceuticalisation" of life [J].
Braillon, Alain ;
Lexchin, Joel ;
Blumsohn, Aubrey ;
Hengartner, Michael P. .
BMJ-BRITISH MEDICAL JOURNAL, 2019, 365
[7]   The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature [J].
Carvalho, Andre F. ;
Sharma, Manu S. ;
Brunoni, Andre R. ;
Vieta, Eduard ;
Fava, Giovanni A. .
PSYCHOTHERAPY AND PSYCHOSOMATICS, 2016, 85 (05) :270-288
[8]   A Meta-Analysis of Cognitive-Behavioural Therapy for Adult Depression, Alone and in Comparison With Other Treatments [J].
Cuijpers, Pim ;
Berking, Matthias ;
Andersson, Gerhard ;
Quigley, Leanne ;
Kleiboer, Annet ;
Dobson, Keith S. .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2013, 58 (07) :376-385
[9]   Omega 3 polyunsaturated fatty acids and the treatment of depression [J].
Deacon, Gelinda ;
Kettle, Christine ;
Hayes, David ;
Dennis, Christina ;
Tucci, Joseph .
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2017, 57 (01) :212-223
[10]  
DSM-5, 2013, DIAGNOSTIC STAT MANU, DOI DOI 10.1176/APPI.BOOKS.9780890425596