To efficiently establish a persistent infection, Kaposi's sarcoma-associated herpesvirus ( KSHV; also known as HHV8) dedicates a large amount of its coding potential to produce proteins that antagonize the immune system of its host. These viral immunomodulators interfere with both the innate and adaptive immune responses and most of them are homologous to cellular proteins, suggesting that they have been pirated from the host during viral evolution. In this Review, I present recent advances in the understanding of immune evasion by KSHV, with a particular focus on the virally encoded modulators of immune responses that are unique to this virus.
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Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USAHarvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USA
Nakamura, H
Li, M
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Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USAHarvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USA
Li, M
Zarycki, J
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Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USAHarvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USA
Zarycki, J
Jung, JU
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Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USAHarvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USA
机构:
Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USAHarvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USA
Nakamura, H
Li, M
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机构:
Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USAHarvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USA
Li, M
Zarycki, J
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h-index: 0
机构:
Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USAHarvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USA
Zarycki, J
Jung, JU
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USAHarvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Tumor Virol, Southborough, MA 01772 USA