Immune evasion by Kaposi's sarcoma-associated herpesvirus

被引：105
作者：
Coscoy, Laurent [1 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 05期
关键词：
D O I：
10.1038/nri2076
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To efficiently establish a persistent infection, Kaposi's sarcoma-associated herpesvirus ( KSHV; also known as HHV8) dedicates a large amount of its coding potential to produce proteins that antagonize the immune system of its host. These viral immunomodulators interfere with both the innate and adaptive immune responses and most of them are homologous to cellular proteins, suggesting that they have been pirated from the host during viral evolution. In this Review, I present recent advances in the understanding of immune evasion by KSHV, with a particular focus on the virally encoded modulators of immune responses that are unique to this virus.
引用
收藏
页码：391 / 401
页数：11
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