Structural homology between bamboo mosaic virus and its satellite RNAs in the 5′ untranslated region

被引：15

作者：

Chen, Shih-Cheng ^{[1
]}

Desprez, Adeline ^{[1
]}

Olsthoorn, Rene C. L. ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, Dept Mol Genet, NL-2300 RA Leiden, Netherlands

来源：

JOURNAL OF GENERAL VIROLOGY | 2010年 / 91卷

关键词：

CIS-ACTING SEQUENCES; STEM-LOOP STRUCTURE; TRIPLE-GENE-BLOCK; MINUS-STRAND RNA; FUNCTIONAL-ANALYSIS; POTEXVIRUS RNA; 5'-UNTRANSLATED REGION; POLY(A) TAIL; GENOMIC RNA; REPLICATION;

D O I：

10.1099/vir.0.015941-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A structural element was identified in the 5'-proximal sequence of the bamboo mosaic virus (BaMV) RNA. Mutational analysis of the hairpin showed that disruptions of the secondary structure or substitutions of the loop sequences resulted in reduced accumulation of BaMV genomic RNA. Phylogenetic analysis further suggested the presence of structural homologues of this hairpin in all other potexviruses. In addition, remarkable structural homology was discovered between the BaMV hairpin and a stem-loop in the 5' untranslated region of satellite RNAs responsible for attenuation of BaMV in co-infected plants. The role of this homology in the helper-satellite interaction is discussed.

引用

页码：782 / 787

页数：6

共 22 条

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