SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis

被引:10
|
作者
Sans-De San Nicolas, Lidia [1 ]
Figueras-Nart, Ignasi [2 ]
Bonfill-Orti, Montserrat [2 ]
De Jesus-Gil, Carmen [1 ]
Garcia-Jimenez, Irene [1 ]
Guilabert, Antonio [3 ]
Curto-Barredo, Laia [4 ]
Bertolin-Colilla, Marta [4 ]
Ferran, Marta [4 ]
Serra-Baldrich, Esther [5 ]
Zalewska-Janowska, Anna [6 ]
Wang, Yui-Hsi [7 ,8 ]
Howell, Michael D. [9 ]
Pujol, Ramon M. [4 ]
Santamaria-Babi, Luis F. [1 ]
机构
[1] Univ Barcelona UB, Fac Biol, Dept Biol Cel lular Fisiol & Immunol, Grp Immunol Translac,Parc Cient Barcelona PCB, Barcelona, Spain
[2] Univ Barcelona UB, Bellvitge Hosp, Dept Dermatol, Lhospitalet De Llobregat, Spain
[3] Hosp Gen Granollers, Dept Dermatologia, Granollers, Spain
[4] Univ Autonoma Barcelona UAB, Inst Hosp Mar Invest Meditques IMIM, Hosp Mar, Dept Dermatol, Barcelona, Spain
[5] Univ Autonoma Barcelona UAB, Hosp Santa Creu & St Pau, Dept Dermatol, Barcelona, Spain
[6] Med Univ Lodz, Psychodermatol Dept, Rheumatol & Clin Immunol, Lodz, Poland
[7] Cincinnati Childrens Hosp Med Ctr, Div Allergy & Immunol, Cincinnati, OH 45229 USA
[8] Sanofi, Type Inflammat & Fibrosis Cluster 2, Immunol & Inflammat Res, Cambridge, MA USA
[9] DermTech Inc, La Jolla, CA USA
关键词
D O I
10.1111/all.15424
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:3448 / 3451
页数:4
相关论文
共 50 条
  • [1] SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis
    Sans-De San Nicolas, L.
    Figueras-Nart, I.
    Bonfill-Orti, M.
    Garcia-Jimenez, I.
    Guilabert-Vidal, A.
    Curto-Barredo, L.
    Ferran, M.
    Serra-Baldrich, E.
    Pujol, R.
    Santamaria-Babi, L.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 142 (12) : S189 - S189
  • [2] SEB-INDUCED IL-13 PRODUCTION IN CLA plus MEMORY T-CELLS DEFINES TH2 HIGH AND TH2 LOW RESPONDERS IN ATOPIC DERMATITIS
    Sans-De San Nicolas, Lidia
    Figueras-Nart, Ignasi
    Bonfill-Orti, Montserrat
    De Jesus-Gil, Carmen
    Garcia-Jimenez, Irene
    Guilabert-Vidal, Antonio
    Curto-Barredo, Laia
    Bertolin-Colilla, Marta
    Ferran, Marta
    Serra-Baldrich, Esther
    Zalewska-Janowska, Anna
    Wang, Yui-Hsi
    Howell, Michael D.
    Pujol, Ramon M.
    Santamaria-Babi, Luis F.
    ACTA DERMATO-VENEREOLOGICA, 2022, 102 : 24 - 25
  • [3] Regulation of IL-13 by histamine in Th2 cells
    Elliott, KA
    Osna, NA
    Scofield, MA
    Khan, MM
    FASEB JOURNAL, 2001, 15 (04): : A662 - A662
  • [4] Early pediatric atopic dermatitis shows only a CLA+ Th2/Th1 imbalance, while adults acquire CLA+ Th22 activation
    Esaki, H.
    Czarnowicki, T.
    Gonzalez, J.
    Malajian, D.
    Talasila, S.
    Berry, A.
    Gray, J.
    Noda, S.
    Krueger, J. G.
    Paller, A. S.
    Guttman-Yassky, E.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 : S29 - S29
  • [5] In vitro activated skin homing (CLA+) T cells in atopic dermatitis spontaneously-secrete and IL-5 and IL-13 dominated Th2 cytokine pattern, help eosinophil survival and induce IgE production.
    Akdis, M
    Akdis, CA
    Weigl, L
    Disch, R
    Simon, HU
    Blaser, K
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 101 (01) : S164 - S164
  • [6] Regulation of IL-4 and IL-13 expression in TH2 cells
    Guo, LY
    Hu-Li, J
    Paul, W
    FASEB JOURNAL, 2005, 19 (04): : A902 - A902
  • [7] Maintenance mechanisms of Th2 cytokine production in memory Th2 cells
    Yamashita, M
    Nakayama, T
    FASEB JOURNAL, 2005, 19 (04): : A22 - A22
  • [8] IL-18 activates human Th2 cells in atopic dermatitis
    Scharli, S.
    Luther, F.
    Werfel, T.
    Thyssen, J. P.
    Eyerich, S.
    Gilliet, M.
    Bertschi, N. L.
    Schlapbach, C.
    SWISS MEDICAL WEEKLY, 2024, 154 : 7S - 7S
  • [9] The Th2 cytokine IL-4 mediates loss of skin δγT cells in atopic dermatitis
    Wang, Jocelyn
    Fu, Yongyao
    Kaplan, Mark H.
    JOURNAL OF IMMUNOLOGY, 2019, 202 (01):
  • [10] A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis
    Grewe, M
    Bruijnzeel-Koomen, CAFM
    Schöpf, E
    Thepen, T
    Langeveld-Wildschut, AG
    Ruzicka, T
    Krutmann, J
    IMMUNOLOGY TODAY, 1998, 19 (08): : 359 - 361