Two new alkaloids isolated from traditional Chinese medicine Binglang the fruit of Areca catechu

被引：22

作者：

Cao, Mengru ^{[1
]}

Yuan, Hanwen ^{[1
]}

Daniyal, Muhammad ^{[1
]}

Yu, Huanghe ^{[1
]}

Xie, Qingling ^{[1
]}

Liu, Yingkai ^{[1
]}

Li, Bin ^{[1
]}

Jian, Yuqing ^{[1
]}

Peng, Caiyun ^{[1
]}

Tan, Dianbo ^{[2
]}

Peng, Yanmei ^{[2
]}

Choudhary, M. Iqbal ^{[1
]}

Rahman, Atta-ur ^{[1
]}

Wang, Wei ^{[1
]}

机构：

[1] Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomed Innovat & Dev Int Lab, Academician Atta Ur Rahamn Belt & Rd Tradit Med R, Changsha 410208, Hunan, Peoples R China

[2] Hunan Acad Chinese Med, Inst Chinese Med, Changsha 410208, Hunan, Peoples R China

来源：

FITOTERAPIA | 2019年 / 138卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Areca catechu; Arecaceae; Alkaloids; Binglang; Structural identification; TCM; PHENOLIC DERIVATIVES; FLAVONOIDS; CONSTITUENTS; ARECOLINE; GLYCOSIDE; INDICA; STEMS;

D O I：

10.1016/j.fitote.2019.104276

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Binglang, the fruit of Areca catechu L, has a long history as an important Chinese herbal medicine. Two new alkaloids (1 and 2), along with forty-one known compounds (3-43) were isolated from the dried fruit of Areca catechu L. The structures were elucidated on basis of the IR, UV, MS and 1D, 2D NMR spectroscopic data. Compounds 26 and 33 showed weak cytotoxicity against human gastric cancer cell line (BGC-823) with IC50 of 15.91 mu M and 20.13 mu M, respectively.

引用

页数：5

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