Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases

被引：6

作者：

Gjorgjievska, Marija ^{[1
]}

Mehandziska, Sanja ^{[1
]}

Stajkovska, Aleksandra ^{[2
]}

Pecioska-Dokuzovska, Slavica ^{[1
]}

Dimovska, Anica ^{[1
]}

Durmish, Idriz ^{[1
]}

Ismail, Sara ^{[1
]}

Pavlovska, Teodora ^{[1
]}

Stojchevska, Antonija ^{[1
]}

Amedi, Haris ^{[1
]}

Andonova, Jasna ^{[1
]}

Nikolovska, Marija ^{[1
]}

Velickovikj, Sara ^{[1
]}

Mitrev, Zan ^{[1
]}

Kungulovski, Ivan ^{[2
]}

Kungulovski, Goran ^{[2
]}

机构：

[1] Zan Mitrev Clin, Skopje, North Macedonia

[2] Bio Engn LLC, Skopje, North Macedonia

来源：

FRONTIERS IN GENETICS | 2022年 / 13卷

关键词：

COVID-19; co-infection; omicron; next-generation sequencing; SARS-CoV2;

D O I：

10.3389/fgene.2022.892682

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Trends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR identified omicron BA.1 at early time-points, which was replaced by omicron BA.2 at later time-points of the infection. The timeline of our data supports the proposition that BA.2 outcompetes BA.1 in a real-life scenario, and in time becomes the dominant variant in the upper respiratory tract of the host.

引用

页数：4

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