Synthesis, characterization, DNA interaction, and cytotoxicity of novel Pd(II) and Pt(II) complexes

被引：9
|
作者：
Gao, Enjun [1 ]
Liu, Fuchun [1 ]
Zhu, Mingchang [1 ]
Wang, Lei [1 ]
Huang, Yun [1 ]
Liu, Hongyan [1 ]
Ma, Shuang [1 ]
Shi, Qunzhi [1 ]
Wang, Ni [1 ]
机构：
[1] Shenyang Inst Chem Technol, Lab Coordinat Chem, Shenyang 110142, Peoples R China
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2010年 / 25卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Pd(II) and Pt(II) complexes; DNA-binding; cleavage; cytotoxic effect; CRYSTAL-STRUCTURE; PLATINUM(II) COMPLEXES; BINDING; PALLADIUM(II); FLUORESCENCE; PHOTOCLEAVAGE; MECHANISM; LIGANDS;
D O I：
10.3109/14756360903357635
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four complexes [Pd(L)(bipy)Cl]center dot 4H(2)O (1), [Pd(L)(phen)Cl]center dot 4H(2)O (2), [Pt(L)(bipy)Cl]center dot 4H(2)O (3), and [Pt(L)(phen) Cl]center dot 4H(2)O (4), where L = quinolinic acid, bipy = 2,2'-bipyridyl, and phen = 1,10-phenanthroline, have been synthesized and characterized using IR, H-1 NMR, elemental analysis, and single-crystal X-ray diffractometry. The binding of the complexes to FS-DNA was investigated by electronic absorption titration and fluorescence spectroscopy. The results indicate that the complexes bind to FS-DNA in an intercalative mode and the intrinsic binding constants K of the title complexes with FS-DNA are about 3.5 x 10(4) M-1, 3.9 x 10(4) M-1, 6.1 x 10(4) M-1, and 1.4 x 10(5) M-1, respectively. Also, the four complexes bind to DNA with different binding affinities, in descending order: complex 4, complex 3, complex 2, complex 1. Gel electrophoresis assay demonstrated the ability of the Pt(II) complexes to cleave pBR322 plasmid DNA.
引用
收藏
页码：557 / 564
页数：8
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