Cellular landscaping of cisplatin resistance in cervical cancer

被引：64

作者：

Bhattacharjee, Rahul ^{[1
]}

Dey, Tanima ^{[1
]}

Kumar, Lamha ^{[2
]}

Kar, Sulagna ^{[1
]}

Sarkar, Ritayan ^{[1
]}

Ghorai, Mimosa ^{[3
]}

Malik, Sumira ^{[4
]}

Jha, Niraj Kumar ^{[5
,6
,7
]}

Vellingiri, Balachandar ^{[8
]}

Kesari, Kavindra Kumar ^{[9
,10
]}

de la Lastra, Jose M. Perez ^{[11
]}

Dey, Abhijit ^{[3
]}

机构：

[1] Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar 751024, Orissa, India

[2] Indian Inst Sci Educ & Res, Sch Biol, Thiruvananthapuram 695551, Kerala, India

[3] Presidency Univ, Dept Life Sci, 86-1 Coll St, Kolkata 700073, W Bengal, India

[4] Amity Univ Jharkhand, Amity Inst Biotechnol, Ranchi 834001, Jharkhand, India

[5] Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Greater Noida 201310, Uttar Pradesh, India

[6] Uttaranchal Univ, Sch Appl & Life Sci SALS, Dept Biotechnol, Dehra Dun 248007, India

[7] Chandigarh Univ, Dept Biotechnol Engn & Food Technol, Mohali 140413, India

[8] Bharathiar Univ, Dept Human Genet & Mol Biol, Human Mol Cytogenet & Stem Cell Lab, Coimbatore 641046, India

[9] Aalto Univ, Sch Sci, Dept Appl Phys, Espoo 00076, Finland

[10] Aalto Univ, Sch Chem Engn, Dept Bioprod & Biosyst, Espoo 00076, Finland

[11] CSIC, Inst Prod Nat & Agrobiol, Biotechnol Macromol, IPNA, Avda Astrofis Francisco Sanchez 3, San Cristobal De La Lagun 38206, Santa Cruz De T, Spain

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 153卷

关键词：

Cervical cancer; Cisplatin resistance; Drug resistance; Anti -cancer activity; Chemotherapeutics; Tumor microenvironment; Cell signaling; CARCINOMA HELA-CELLS; HEAT-SHOCK-PROTEIN; IN-VITRO; TUMOR MICROENVIRONMENT; INDUCED APOPTOSIS; HIPPO PATHWAY; VITAMIN-C; PHOTODYNAMIC THERAPY; MULTIDRUG-RESISTANCE; MOLECULAR-MECHANISMS;

D O I：

10.1016/j.biopha.2022.113345

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of malignancies in women worldwide. Cisplatin is one of the widely used drugs for the treatment of CC is rendered ineffective owing to drug resistance. This review highlights the cause of resistance and the mechanism of cisplatin resistance cells in CC to develop therapeutic ventures and strategies that could be utilized to overcome the aforementioned issue. These strategies would include the application of nanocarries, miRNA, CRIPSR/Cas system, and chemotherapeutics in synergy with cisplatin to not only overcome the issues of drug resistance but also enhance its anticancer efficiency. Moreover, we have also discussed the signaling network of cisplatin resistance cells in CC that would provide insights to develop therapeutic target sites and inhibitors. Furthermore, we have discussed the role of CC metabolism on cisplatin resistance cells and the physical and biological factors affecting the tumor microenvironments.

引用

页数：18

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