EBV-infected B cells in infectious mononucleosis:: Viral strategies for spreading in the B cell compartment and establishing latency

被引：173

作者：

Kurth, J ^{[1
]}

Spieker, T

Wustrow, J

Strickler, JG

Hansmann, ML

Rajewsky, K

Küppers, R

机构：

[1] Univ Cologne, Inst Genet, D-50931 Cologne, Germany

[2] Univ Cologne, Dept Internal Med 1, D-50931 Cologne, Germany

[3] Goethe Univ Frankfurt, Dept Pathol, D-60590 Frankfurt, Germany

[4] St Elizabeth Hosp, D-50935 Cologne, Germany

[5] Allina Labs, Minneapolis, MN 55407 USA

来源：

IMMUNITY | 2000年 / 13卷 / 04期

关键词：

D O I：

10.1016/S1074-7613(00)00048-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infection of humans with Epstein-Barr virus (EBV) may cause infectious mononucleosis (IM). Analysis of single EBV-infected cells from tonsils of IM patients for rearranged immunoglobulin genes revealed two strategies of EBV for rapid and massive spread in the B cell compartment: the direct infection of many naive as well as memory and/or germinal center B cells and the expansion of the latter cells to large clones. In IM, the generation of virus-harboring memory B cells from naive B cells passing through a germinal center reaction likely plays no role. Members of clones can show distinct morphologies and likely also EBV gene expression patterns, and this ability implies a mechanism by which EBV-harboring cells can evade immune surveillance and establish a pool of persisting EBV-infected B cells.

引用

页码：485 / 495

页数：11

共 57 条

[1] EARLY EVENTS IN EPSTEIN-BARR-VIRUS INFECTION OF HUMAN LYMPHOCYTES-B [J].