Pathological complete response of a metastatic MisMatch Repair deficient/MicroSatellite Instable colon cancer after immunotherapy: A case report

被引:2
作者
Brochard, Camille [1 ]
Chicaud, Matthieu [1 ]
Colle, Raphael [2 ]
Parc, Yann [3 ]
Svrcek, Magali [1 ]
机构
[1] Sorbonne Univ, Hop St Antoine, Assistance Publ Hop Paris AP HP, Serv Anat & Cytol Pathol, 184 Rue Faubourg St Antoine, F-75012 Paris, France
[2] Sorbonne Univ, Hop St Antoine, Assistance Publ Hop Paris AP HP, Serv Oncol Med, 184 Rue Faubourg St Antoine, F-75012 Paris, France
[3] Sorbonne Univ, Hop St Antoine, Assistance Publ Hop Paris AP HP, Serv Chirurg Gen & Digest, 184 Rue Faubourg St Antoine, F-75012 Paris, France
关键词
Colorectal cancer; Immunotherapy; Microsatelite instability; Pathological complete response; OUTCOMES; TUMORS;
D O I
10.1016/j.annpat.2021.12.008
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Immunotherapies are part of the therapeutic strategy in many cancers and are indicated for metastatic colorectal adenocarcinoma with loss of expression of MisMatch Repair system proteins or with microsatelite instability (dMMR/MSI) in the United States. The rate of pathological response to immunotherapy remains poorly documented, but several cases of complete or major pathological response have recently been described. We decided to report the case of a complete pathological response to immunotherapy of a dMMR/MSI colorectal adenocarcinoma in a 74-year-old patient, initially inoperable due to duodenal invasion. Three months after the introduction of immunotherapy, the patient developed drug-induced colitis that contraindicated further treatment. Histological examination of the subtotal colectomy specimen revealed no residual tumour cells. The patterns of tumour regression were mainly represented by colloid regression, infarctoid-type necrosis and a resorptive inflammatory reaction. Although the operative indications for patients with metastatic dMMR/MSI colorectal cancer treated by immunotherapy are still very limited, the number of such specimens is expected to increase rapidly. The management of these specimens, as well as the possibility of a complete histological response, must be known by pathologists who play a key role in the pathophysiological knowledge of these lesions. (c) 2021 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:172 / 176
页数:5
相关论文
共 10 条
  • [1] Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer
    Andre, T.
    Shiu, K-K
    Kim, T. W.
    Jensen, B., V
    Jensen, L. H.
    Punt, C.
    Smith, D.
    Garcia-Carbonero, R.
    Benavides, M.
    Gibbs, P.
    de la Fouchardiere, C.
    Rivera, F.
    Elez, E.
    Bendell, J.
    Le, D. T.
    Yoshino, T.
    Van Cutsem, E.
    Yang, P.
    Farooqui, M. Z. H.
    Marinello, P.
    Diaz, L. A., Jr.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) : 2207 - 2218
  • [2] Association of Pathologic Complete Response to Neoadjuvant Therapy in HER2-Positive Breast Cancer With Long-Term Outcomes A Meta-Analysis
    Broglio, Kristine R.
    Quintana, Melanie
    Foster, Margaret
    Olinger, Melissa
    McGlothlin, Anna
    Berry, Scott M.
    Boileau, Jean-Francois
    Brezden-Masley, Christine
    Chia, Stephen
    Dent, Susan
    Gelmon, Karen
    Paterson, Alexander
    Rayson, Daniel
    Berry, Donald A.
    [J]. JAMA ONCOLOGY, 2016, 2 (06) : 751 - 760
  • [3] Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers
    Chalabi, Myriam
    Fanchi, Lorenzo F.
    Dijkstra, Krijn K.
    Van den Berg, Jose G.
    Aalbers, Arend G.
    Sikorska, Karolina
    Lopez-Yurda, Marta
    Grootscholten, Cecile
    Beets, Geerard L.
    Snaebjornsson, Petur
    Maas, Monique
    Mertz, Marjolijn
    Veninga, Vivien
    Bounova, Gergana
    Broeks, Annegien
    Beets-Tan, Regina G.
    de Wijkerslooth, Thomas R.
    van Lent, Anja U.
    Marsman, Hendrik A.
    Nuijten, Elvira
    Kok, Niels F.
    Kuiper, Maria
    Verbeek, Wieke H.
    Kok, Marleen
    Van Leerdam, Monique E.
    Schumacher, Ton N.
    Voest, Emile E.
    Haanen, John B.
    [J]. NATURE MEDICINE, 2020, 26 (04) : 566 - +
  • [4] A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma
    Huang, Alexander C.
    Orlowski, Robert J.
    Xu, Xiaowei
    Mick, Rosemarie
    George, Sangeeth M.
    Yan, Patrick K.
    Manne, Sasikanth
    Kraya, Adam A.
    Wubbenhorst, Bradley
    Dorfman, Liza
    D'Andrea, Kurt
    Wenz, Brandon M.
    Liu, Shujing
    Chilukuri, Lakshmi
    Kozlov, Andrew
    Carberry, Mary
    Giles, Lydia
    Kier, Melanie W.
    Quagliarello, Felix
    McGettigan, Suzanne
    Kreider, Kristin
    Annamalai, Lakshmanan
    Zhao, Qing
    Mogg, Robin
    Xu, Wei
    Blumenschein, Wendy M.
    Yearley, Jennifer H.
    Linette, Gerald P.
    Amaravadi, Ravi K.
    Schuchter, Lynn M.
    Herati, Ramin S.
    Bengsch, Bertram
    Nathanson, Katherine L.
    Farwell, Michael D.
    Karakousis, Giorgos C.
    Wherry, E. John
    Mitchell, Tara C.
    [J]. NATURE MEDICINE, 2019, 25 (03) : 454 - +
  • [5] PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
    Le, D. T.
    Uram, J. N.
    Wang, H.
    Bartlett, B. R.
    Kemberling, H.
    Eyring, A. D.
    Skora, A. D.
    Luber, B. S.
    Azad, N. S.
    Laheru, D.
    Biedrzycki, B.
    Donehower, R. C.
    Zaheer, A.
    Fisher, G. A.
    Crocenzi, T. S.
    Lee, J. J.
    Duffy, S. M.
    Goldberg, R. M.
    de la Chapelle, A.
    Koshiji, M.
    Bhaijee, F.
    Huebner, T.
    Hruban, R. H.
    Wood, L. D.
    Cuka, N.
    Pardoll, D. M.
    Papadopoulos, N.
    Kinzler, K. W.
    Zhou, S.
    Cornish, T. C.
    Taube, J. M.
    Anders, R. A.
    Eshleman, J. R.
    Vogelstein, B.
    Diaz, L. A., Jr.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (26) : 2509 - 2520
  • [6] Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
    Le, Dung T.
    Durham, Jennifer N.
    Smith, Kellie N.
    Wang, Hao
    Bartlett, Bjarne R.
    Aulakh, Laveet K.
    Lu, Steve
    Kemberling, Holly
    Wilt, Cara
    Luber, Brandon S.
    Wong, Fay
    Azad, Nilofer S.
    Rucki, Agnieszka A.
    Laheru, Dan
    Donehower, Ross
    Zaheer, Atif
    Fisher, George A.
    Crocenzi, Todd S.
    Lee, James J.
    Greten, Tim F.
    Duffy, Austin G.
    Ciombor, Kristen K.
    Eyring, Aleksandra D.
    Lam, Bao H.
    Joe, Andrew
    Kang, S. Peter
    Holdhoff, Matthias
    Danilova, Ludmila
    Cope, Leslie
    Meyer, Christian
    Zhou, Shibin
    Goldberg, Richard M.
    Armstrong, Deborah K.
    Bever, Katherine M.
    Fader, Amanda N.
    Taube, Janis
    Housseau, Franck
    Spetzler, David
    Xiao, Nianqing
    Pardoll, Drew M.
    Papadopoulos, Nickolas
    Kinzler, Kenneth W.
    Eshleman, James R.
    Vogelstein, Bert
    Anders, Robert A.
    Diaz, Luis A., Jr.
    [J]. SCIENCE, 2017, 357 (6349) : 409 - 413
  • [7] Pathological Tumor Response Following Immune Checkpoint Blockade for Deficient Mismatch Repair Advanced Colorectal Cancer
    Ludford, Kaysia
    Cohen, Romain
    Svrcek, Magali
    Foo, Wai Chin
    Colle, Raphael
    Parc, Yann
    Thomas, Jane Varkey
    Morris, Van Karlyle
    Kopetz, Scott
    Chang, George J.
    Overman, Michael
    Andre, Thierry
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2021, 113 (02): : 208 - 211
  • [8] Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
    Overman, Michael J.
    McDermott, Ray
    Leach, Joseph L.
    Lonardi, Sara
    Lenz, Heinz-Josef
    Morse, Michael A.
    Desai, Jayesh
    Hill, Andrew
    Axelson, Michael
    Moss, Rebecca A.
    Goldberg, Monica V.
    Cao, Z. Alexander
    Ledeine, Jean-Marie
    Maglinte, Gregory A.
    Kopetz, Scott
    Andre, Thierry
    [J]. LANCET ONCOLOGY, 2017, 18 (09) : 1182 - 1191
  • [9] Histopathologic Response Criteria Predict Survival of Patients with Resected Lung Cancer After Neoadjuvant Chemotherapy
    Pataer, Apar
    Kalhor, Neda
    Correa, Arlene M.
    Raso, Maria Gabriela
    Erasmus, Jeremy J.
    Kim, Edward S.
    Behrens, Carmen
    Lee, J. Jack
    Roth, Jack A.
    Stewart, David J.
    Vaporciyan, Ara A.
    Wistuba, Ignacio I.
    Swisher, Stephen G.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2012, 7 (05) : 825 - 832
  • [10] Rationale and Outcomes for Neoadjuvant Immunotherapy in Urothelial Carcinoma of the Bladder
    Rouanne, Mathieu
    Bajorin, Dean F.
    Hannan, Raquibul
    Galsky, Matthew D.
    Williams, Stephen B.
    Necchi, Andrea
    Sharma, Padmanee
    Powles, Thomas
    [J]. EUROPEAN UROLOGY ONCOLOGY, 2020, 3 (06): : 728 - 738