Own and Parental Predictors of Low Blood Level of High Density Lipoprotein Cholesterol in Offspring of Persons With Early Coronary Heart Disease

Aim: to elucidate own and parental predictors of low levels of high density lipoprotein cholesterol (HDL-C) in blood of children of persons with early coronary heart disease (ECHD) (onset <= 55 years, men, or <= 60 years, women). Methods. We examined 305 families: probands with ECAD (n=289, 69.2% men), their spouses (n=213, 17.8% men) and native children of probands (n=399, 56.1% men) aged 5-38 years. Low level of HDL-C in children aged 5-17 years we defined as <= 25 percentile (the Lipid Research Clinics, 1981), in children aged 18-38 years <1.03 (men) and <1.29 (women) mmol/l. Predictors of low HDL-C were selected by logistical regression with adjustment for sex and age. Results. Low HDL-C was revealed in 48/152 (31.6%) children aged 5-17 years. Its independent predictors were own higher triglycerides (TG) and low HDL-C of spouse. Odds ratio (OR) of top (>0.94 mmol/l) vs two bottom (<= 0.94 mmol/l) tertiles of TG 2.68 (95% confidence interval [CI] 1.03-6.94; p= 0.043); low HDL-C of spouse 2.33 (95% CI 1.03-5.26; p= 0.041). Low HDL-C was revealed in,91/247 (36.8%) offsprings aged 18-38 years. Its independent predictors were higher waist circumferences (WC, OR top [> 85 cm] vs bottom [<= 73 cm] tertile 5.43, 95% CI 2.39-12.3; p= 0.000) and TG (OR 1.45, 95% CI 1.01-2.09; p= 0.047) of these children, atherogenic dyslipidemia of proband (OR 2.44, 95% CI 1.34-4.44; p= 0.0036); metabolic syndrome (OR 4.14, 95% CI 1.96-8.75; p= 0.0002) and lower heart rate (OR top [>72 bpm] vs two bottom [<= 72 bpm] tertiles 0.41, 95% CI 0.17-0.97; p= 0.043) of consort-parent. Conclusions. In this group of different age children with parental ECHD independent predictors of low HDL-C were mostly own (TG) and parental metabolic factors.