SOX9: An emerging driving factor from cancer progression to drug resistance

被引：76

作者：

Panda, Munmun ^{[1
]}

Tripathi, Surya Kant ^{[1
]}

Biswal, Bijesh K. ^{[1
]}

机构：

[1] Natl Inst Technol Rourkela, Dept Life Sci, Canc Drug Resistance Lab, Rourkela 769008, Odisha, India

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2021年 / 1875卷 / 02期

关键词：

SOX9; Cancer; Signaling; EMT; CSC; Drug resistance; INHIBITS CELL-PROLIFERATION; AUTOSOMAL SEX REVERSAL; DIRECTLY TARGETS SOX9; BREAST-CANCER; TRANSCRIPTION FACTORS; GASTRIC-CANCER; UP-REGULATION; STEM-CELLS; TUMOR PROGRESSION; CERVICAL-CANCER;

D O I：

10.1016/j.bbcan.2021.188517

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dysregulation of transcription factors is one of the common problems in the pathogenesis of human cancer. Among them, SOX9 is one of the critical transcription factors involved in various diseases, including cancer. The expression of SOX9 is regulated by microRNAs (miRNAs), methylation, phosphorylation, and acetylation. Interestingly, SOX9 acts as a proto-oncogene or tumor suppressor gene, relying upon kinds of cancer. Recent studies have reported the critical role of SOX9 in the regulation of the tumor microenvironment (TME). Additionally, activation of SOX9 signaling or SOX9 regulated signaling pathways play a crucial role in cancer development and progression. Accumulating evidence also suggests that SOX9 acquires stem cell features to induce epithelial-mesenchymal transition (EMT). Moreover, SOX9 has been broadly studied in the field of cancer stem cell (CSC) and EMT in the last decades. However, the link between SOX9 and cancer drug resistance has only recently been discovered. Furthermore, its differential expression could be a potential biomarker for tumor prognosis and progression. This review outlined the various biological implications of SOX9 in cancer progression and cancer drug resistance and elucidated its signaling network, which could be a potential target for designing novel anticancer drugs.

引用

页数：15

共 198 条

[1] MiniSOX9, a dominant-negative variant in colon cancer cells [J].

Abdel-Samad, R. ;

Zalzali, H. ;

Rammah, C. ;

Giraud, J. ;

Naudin, C. ;

Dupasquier, S. ;

Poulat, F. ;

Boizet-Bonhoure, B. ;

Lumbroso, S. ;

Mouzat, K. ;

Bonnans, C. ;

Pignodel, C. ;

Raynaud, P. ;

Fort, P. ;

Quittau-Prevostel, C. ;

Blache, P. .

ONCOGENE, 2011, 30 (22) :2493-2503

[2] Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa [J].

Akiyama, H ;

Chaboissier, MC ;

Behringer, RR ;

Rowitch, DH ;

Schedl, A ;

Epstein, JA ;

de Crombrugghe, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) :6502-6507

[3] Identification of DNA hypermethylation of SOX9 in association with bladder cancer progression using CpG microarrays [J].

Aleman, A. ;

Adrien, L. ;

Lopez-Serra, L. ;

Cordon-Cardo, C. ;

Esteller, M. ;

Belbin, T. J. ;

Sanchez-Carbayo, M. .

BRITISH JOURNAL OF CANCER, 2008, 98 (02) :466-473

[4] Skeletal dysplasias and the growth plate [J].

Alman, B. A. .

CLINICAL GENETICS, 2008, 73 (01) :24-30

[5] AACR Project GENIE: Powering Precision Medicine through an International Consortium [J].

Andre, Fabrice ;

Arnedos, Monica ;

Baras, Alexander S. ;

Baselga, Jose ;

Bedard, Philippe L. ;

Berger, Michael F. ;

Bierkens, Mariska ;

Calvo, Fabien ;

Cerami, Ethan ;

Chakravarty, Debyani ;

Dang, Kristen K. ;

Davidson, Nancy E. ;

Del Vecchio, Fitz Catherine ;

Dogan, Semih ;

DuBois, Raymond N. ;

Ducar, Matthew D. ;

Futreal, P. Andrew ;

Gao Jianjiong ;

Garcia, Francisco ;

Gardos, Stu ;

Gocke, Christopher D. ;

Gross, Benjamin E. ;

Guinney, Justin ;

Heins, Zachary J. ;

Hintzen, Stephanie ;

Horlings, Hugo ;

Hudecek, Jan ;

Hyman, David M. ;

Kamel-Reid, Suzanne ;

Kandoth, Cyriac ;

Kinyua, Walter ;

Kumari, Priti ;

Kundra, Ritika ;

Ladanyi, Marc ;

Lefebvre, Celine ;

LeNoue-Newton, Michele L. ;

Lepisto, Eva M. ;

Levy, Mia A. ;

Lindeman, Neal, I ;

Lindsay, James ;

Liu, David ;

Lu Zhibin ;

MacConaill, Laura E. ;

Ian, Maurer ;

Maxwell, David S. ;

Meijer, Gerrit A. ;

Meric-Bernstam, Funda ;

Micheel, Christine M. ;

Miller, Clinton ;

Mills, Gordon .

CANCER DISCOVERY, 2017, 7 (08) :818-831

[6] A decade of exploring the cancer epigenome - biological and translational implications [J].

Baylin, Stephen B. ;

Jones, Peter A. .

NATURE REVIEWS CANCER, 2011, 11 (10) :726-734

[7] Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency [J].

Behnan, J. ;

Stangeland, B. ;

Hosainey, S. A. M. ;

Joel, M. ;

Olsen, T. K. ;

Micci, F. ;

Glover, J. C. ;

Isakson, P. ;

Brinchmann, J. E. .

ONCOGENE, 2017, 36 (04) :570-584

[8] SOX9 directly regulates the type-II collagen gene [J].

Bell, DM ;

Leung, KKH ;

Wheatley, SC ;

Ng, LJ ;

Zhou, S ;

Ling, KW ;

Sham, MH ;

Koopman, P ;

Tam, PPL ;

Cheah, KSE .

NATURE GENETICS, 1997, 16 (02) :174-178

[9] The Role of SOX9 Transcription Factor in Pancreatic and Duodenal Development [J].

Belo, Jamie ;

Krishnamurthy, Mansa ;

Oakie, Amanda ;

Wang, Rennian .

STEM CELLS AND DEVELOPMENT, 2013, 22 (22) :2935-2943

[10] Global Genome Analysis of the Downstream Binding Targets of Testis Determining Factor SRY and SOX9 [J].

Bhandari, Ramji K. ;

Haque, Md. M. ;

Skinner, Michael K. .

PLOS ONE, 2012, 7 (09)

← 1 2 3 4 5 6 7 8 9 10 →