Synthesis of some imidazolyl-thioacetyl-pyrazolinone derivatives and their antinociceptive and anticancer activities

被引：8

作者：

Demirayak, Seref ^{[1
]}

Kayagil, Ismail ^{[1
]}

Yurttas, Leyla ^{[1
]}

Aslan, Rana ^{[2
]}

机构：

[1] Univ Anadolu, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey

[2] Univ Anadolu, Fac Pharm, Dept Pharmacol, TR-26470 Eskisehir, Turkey

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2010年 / 25卷 / 01期

关键词：

1,5-diarylimidazole-2-thione; 3-pyrazoline-5-one; antinociceptive activity; anticancer activity; BIOLOGICAL EVALUATION; SELECTIVE INHIBITORS; CYCLOOXYGENASE-2; INHIBITORS; COX-2; POTENT; DESIGN; SERIES; IDENTIFICATION; SUBSTITUENTS; APOPTOSIS;

D O I：

10.3109/14756360903016751

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, some 4-(1,5-diarylimidazol-2-yl)thioacetyl-1-phenyl-2,3-dimethyl-3-pyrazoline-5-one derivatives were prepared by reacting 4-(2-chloroacetyl)-1-phenyl-2,3-dimethyl-3-pyrazoline-5-one and 2-mercapto-1, 5-diarylimidazole derivatives. The antinociceptive and anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, 2a, 2d, 2g, and 2j, showed remarkable antinociceptive activity, and one of the compounds, 2i, showed weak anticancer activity.

引用

页码：74 / 79

页数：6

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