A gut-brain neural circuit for nutrient sensory transduction

被引：640

作者：

Kaelberer, Melanie Maya ^{[1
]}

Buchanan, Kelly L. ^{[2
]}

Klein, Marguerita E. ^{[1
]}

Barth, Bradley B. ^{[3
]}

Montoya, Marcia M. ^{[3
]}

Shen, Xiling ^{[3
]}

Bohorquez, Diego V. ^{[1
,4
,5
]}

机构：

[1] Duke Univ, Dept Med, Durham, NC 27708 USA

[2] Duke Univ, Sch Med, Durham, NC USA

[3] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA

[4] Duke Univ, Dept Neurobiol, Durham, NC 27708 USA

[5] Duke Univ, Duke Inst Brain Sci, Durham, NC 27708 USA

来源：

SCIENCE | 2018年 / 361卷 / 6408期

关键词：

GLUCAGON-LIKE PEPTIDE-1; ENTEROCHROMAFFIN CELLS; IN-VIVO; SINGLE; RAT; GLUTAMATE; NEURONS; NEUROTRANSMITTER; ORGANIZATION; SECRETION;

D O I：

10.1126/science.aat5236

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The brain is thought to sense gut stimuli only via the passive release of hormones. This is because no connection has been described between the vagus and the putative gut epithelial sensor cell-the enteroendocrine cell. However, these electrically excitable cells contain several features of epithelial transducers. Using a mouse model, we found that enteroendocrine cells synapse with vagal neurons to transduce gut luminal signals inmilliseconds by using glutamate as a neurotransmitter. These synaptically connected enteroendocrine cells are referred to henceforth as neuropod cells. The neuroepithelial circuit they form connects the intestinal lumen to the brainstem in one synapse, opening a physical conduit for the brain to sense gut stimuli with the temporal precision and topographical resolution of a synapse.

引用

页码：1219 / +

页数：9

共 29 条

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