Copper/Guanidine-Catalyzed Asymmetric Alkynylation of Isatins

被引：103

作者：

Chen, Quangang ^{[1
]}

Tang, Yu ^{[1
]}

Huang, Tianyu ^{[1
]}

Liu, Xiaohua ^{[1
]}

Lin, Lili ^{[1
]}

Feng, Xiaoming ^{[1
,2
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 17期

基金：

中国国家自然科学基金;

关键词：

alkynes; asymmetric catalysis; copper; heterocycles; ligand design; HIGHLY ENANTIOSELECTIVE ADDITION; AROMATIC-ALDEHYDES; TERMINAL ALKYNES; PROPARGYLIC ALCOHOLS; TRIFLUOROMETHYL KETONES; COORDINATION CHEMISTRY; CONVENIENT SYNTHESIS; TITANIUM COMPLEX; CARBONYL GROUPS; H INSERTION;

D O I：

10.1002/anie.201600711

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The highly enantioselective alkynylation of isatins, catalyzed by a bifunctional guanidine/CuI catalyst under mild reaction conditions, is described. The reaction is broad in scope with respect to alkyl/aryl-substituted terminal alkynes and substituted isatins, thus affording bioactive propargylic alcohols in excellent yields and enantioselectivities.

引用

页码：5286 / 5289

页数：4

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