Mitophagy in Viral Infections

被引：11

作者：

Xia, Mao ^{[1
]}

Meng, Gang ^{[1
]}

Li, Min ^{[1
]}

Wei, Jiwu ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Med, Jiangsu Key Lab Mol Med, Nanjing 210093, Jiangsu, Peoples R China

来源：

DNA AND CELL BIOLOGY | 2014年 / 33卷 / 11期

基金：

中国国家自然科学基金;

关键词：

MEASLES-VIRUS; CELL-DEATH; AUTOPHAGY; APOPTOSIS; MITOCHONDRIA; IMMUNITY; CANCER; PHOSPHORYLATION; REPLICATION; RECOGNITION;

D O I：

10.1089/dna.2014.2567

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antiviral innate immune responses and apoptosis are the two major factors limiting viral infections. Successful viral infection requires the virus to take advantage of the cellular machinery to bypass cellular defenses. Accumulated evidences show that autophagy plays a crucial role in cell-to-virus interaction. Here, we focus on how viruses subvert mitophagy to favor viral replication by mitigating innate immune responses and apoptotic signaling.

引用

页码：739 / 742

页数：4

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