Innate immune responses to microbial poisons: Discovery and function of the toll-like receptors

被引:67
作者
Beutler, B [1 ]
机构
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
关键词
LPS; lipopolysaccharide; TNF; toll-like receptors; TLR4; innate immunity;
D O I
10.1146/annurev.pharmtox.43.100901.135729
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
There are many circumstances under which a toxin exploits an endogenous receptor or another protein of host origin to work its untoward effects. In most instances, the receptor normally fulfills a function that has nothing to do with the toxin per se; that is, the toxin is not the "natural" ligand. The situation with endotoxin, however, is a remarkable one. The endotoxin receptor evolved to detect endotoxin. Why have mammals maintained a gene that can undermine their survival? The search for the endotoxin receptor answered this question and also revealed the essential function and biological strategy of the Toll-like receptors: principal sensors of the innate immune system.
引用
收藏
页码:609 / 628
页数:22
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