Argonaute 3 (AGO3) promotes malignancy potential of cervical cancer via regulation of Wnt/β-catenin signaling pathway

被引：4

作者：

Pan, Liuliu ^{[1
,2
]}

Xu, Chaoyi ^{[1
,2
]}

Mei, Jie ^{[1
,2
]}

Chen, Yizhe ^{[1
,2
]}

Wang, Danhan ^{[1
,2
]}

机构：

[1] Wenzhou Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 2, Wenzhou 325027, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China

来源：

REPRODUCTIVE BIOLOGY | 2021年 / 21卷 / 01期

关键词：

Argonaute 3 (AGO3); Cervical cancer; Wnt/beta-catenin signaling pathway; Cell viability; Mobility; EXPRESSION; PROGRESSION; ACTIVATION; REDUCTION; DICER; CELLS;

D O I：

10.1016/j.repbio.2020.100479

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We aimed to investigate the biological roles of Argonaute 3 (AGO3) in cervical cancer. RNA profiles containing 306 cervical cancer tissues and 13 normal samples revealed that AGO3 was significantly up-regulated in cervical cancer, and the expression of AGO3 was negatively associated with the outcome of cervical cancer patients. Cell proliferation and transwell assays showed that the depletion of AGO3 markedly inhibited cervical cancer cell growth and mobility. Importantly, we detected that knockdown of AGO3 exerted suppressive effect on cellular behaviors via inactivating Wnt/beta-catenin signaling pathway. Collectively, we conclude that AGO3 is a novel tumor promoter in cervical cancer and has a potential to be a drug target and prognostic predictor of cervical cancer patients. (C) 2021 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.

引用

页数：7

共 37 条

[1] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[2] Key Molecular Events in Cervical Cancer Development [J].

Balasubramaniam, Shandra Devi ;

Balakrishnan, Venugopal ;

Oon, Chern Ein ;

Kaur, Gurjeet .

MEDICINA-LITHUANIA, 2019, 55 (07)

[3] Down-regulation of Dicer and Ago2 is associated with cell proliferation and apoptosis in prostate cancer [J].

Bian, Xiao-Jie ;

Zhang, Gui-Ming ;

Gu, Cheng-Yuan ;

Cai, Ying ;

Wang, Chao-Fu ;

Shen, Yi-Jun ;

Zhu, Yao ;

Zhang, Hai-Liang ;

Dai, Bo ;

Ye, Ding-Wei .

TUMOR BIOLOGY, 2014, 35 (11) :11571-11578

[4]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[5] SALL4 promotes the tumorigenicity of cervical cancer cells through activation of the Wnt/β-catenin pathway via CTNNB1 [J].

Chen, Mei ;

Li, Lu ;

Zheng, Peng-Sheng .

CANCER SCIENCE, 2019, 110 (09) :2794-2805

[6] EZH2-mediated repression of GSK-3β and TP53 promotes Wnt/β-catenin signaling-dependent cell expansion in cervical carcinoma [J].

Chen, Qian ;

Zheng, Peng-Sheng ;

Yang, Wen-Ting .

ONCOTARGET, 2016, 7 (24) :36115-36129

[7] Wnt signaling to β-catenin involves two interactive components -: Glycogen synthase kinase-3β inhibition and activation of protein kinase C [J].

Chen, RH ;

Ding, WV ;

McCormick, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (23) :17894-17899

[8] mRNA expression profiles show differential regulatory effects of microRNAs between estrogen receptor-positive and estrogen receptor-negative breast cancer [J].

Cheng, Chao ;

Fu, Xuping ;

Alves, Pedro ;

Gerstein, Mark .

GENOME BIOLOGY, 2009, 10 (09)

[9] Cervical Cancer Screening Programs in Europe: The Transition Towards HPV Vaccination and Population-Based HPV Testing [J].

Chrysostomou, Andreas C. ;

Stylianou, Dora C. ;

Constantinidou, Anastasia ;

Kostrikis, Leondios G. .

VIRUSES-BASEL, 2018, 10 (12)

[10] Slug inhibits the proliferation and tumor formation of human cervical cancer cells by up-regulating the p21/p27 proteins and down-regulating the activity of the Wnt/β-catenin signaling pathway via the trans-suppression Akt1/p-Akt1 expression [J].

Cui, Nan ;

Yang, Wen-Ting ;

Zheng, Peng-Sheng .

ONCOTARGET, 2016, 7 (18) :26152-26167

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