Hematopoietic Stem Cell Transplantation for Patients with Sickle Cell Disease Progress and Future Directions

被引：44

作者：

Fitzhugh, Courtney D. ^{[1
]}

Abraham, Allistair A. ^{[1
]}

Tisdale, John F. ^{[1
]}

Hsieh, Matthew M. ^{[1
]}

机构：

[1] George Washington Univ, Sch Med & Hlth Sci, Childrens Natl Hlth Syst, Div Blood & Marrow Transplantat, Washington, DC 20010 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2014年 / 28卷 / 06期

关键词：

Sickle cell disease; Matched sibling donor; Cord blood (CB) donor; Haploidentical donor; Matched unrelated donor; BONE-MARROW-TRANSPLANTATION; CORD BLOOD TRANSPLANTATION; ANTI-HLA ANTIBODIES; BETA-THALASSEMIA; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE; CONDITIONING REGIMEN; UNRELATED DONORS; SIBLING DONORS; GRAFT FAILURE; ANEMIA;

D O I：

10.1016/j.hoc.2014.08.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Research has solidified matched sibling marrow, cord blood, or mobilized peripheral blood as the best source for allogeneic hematopoietic stem cell transplantation for patients with sickle cell disease, with low graft rejection and graft-versus-host disease (GVHD) and high disease-free survival rates. Fully allelic matched unrelated donor is an option for transplant-eligible patients without HLA-matched sibling donors. Unrelated cord transplant studies reported high GVHD and low engraftment rates. Haploidentical transplants have less GVHD, but improvements are needed to increase the low engraftment rate. The decision to use unrelated cord blood units or haploidentical donors depends on institutional expertise.

引用

页码：1171 / +

页数：16

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