Paucity of HPV-Related Head and Neck Cancers (HNC) in Nigeria

被引:20
|
作者
Oga, Emmanuel A. [1 ,2 ]
Schumaker, Lisa M. [3 ]
Alabi, Biodun Sulyman [4 ]
Obaseki, Darlington [5 ]
Umana, Aniefon [6 ]
Bassey, Ima-Abasi [6 ]
Ebughe, Godwin [6 ]
Oluwole, Olabode [7 ]
Akeredolu, Teniola [2 ]
Adebamowo, Sally N. [2 ,8 ,9 ]
Dakum, Patrick [2 ]
Cullen, Kevin [3 ]
Adebamowo, Clement A. [1 ,2 ,3 ,8 ]
机构
[1] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA
[2] Inst Human Virol Nigeria, Off Res Training & Strateg Informat, Abuja, Fct, Nigeria
[3] Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA
[4] Univ Ilorin Teaching Hosp, Dept Ear Nose & Throat Head & Neck Surg, Ilorin, Kwara State, Nigeria
[5] Univ Benin Teaching Hosp, Benin, Edo State, Nigeria
[6] Univ Calabar Teaching Hosp, Calabar, Cross River Sta, Nigeria
[7] Univ Abuja Teaching Hosp, Abuja, Fct, Nigeria
[8] Harvard Univ, Dept Nutr, TH Chan Sch Publ Hlth, Boston, MA 02115 USA
[9] NHGRI, NIH, Bethesda, MD 20892 USA
来源
PLOS ONE | 2016年 / 11卷 / 04期
关键词
SQUAMOUS-CELL CARCINOMAS; PAPILLOMAVIRUS-ASSOCIATED HEAD; INCIDENCE TRENDS; ORAL SEX; PREVALENCE; INFECTION; ADOLESCENTS; SMOKING; IMPACT; TUMORS;
D O I
10.1371/journal.pone.0152828
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Introduction The burden of HPV-related Head and Neck Cancers (HNC) has been rising in the U.S. and other developed countries but this trend has not been reported in Africa. Objective of study was to evaluate the prevalence of HPV infection in HNC cancer cases seen between 1990 and 2011 at the tertiary health care institutions in Nigeria. Methods We retrieved 149 head and neck cancer formalin fixed, paraffin embedded tumor specimens diagnosed between 1990 and 2011 from four teaching hospitals in Nigeria. One hundred and twenty-three blocks (83%) contained appropriate HNC for analysis while DNA extraction was successful in 60% (90/149). PCR amplification was successful in 33% (49/149) and Linear Array genotyping for HPV was successful in 11% (17/149) of these cases. These were in tumors from the larynx (6), cervical lymph nodes (3), nasal cavity (2), parotid (1), palate (1), maxillary sinus (1) and mandible (1). Two cases were non-specific and none were from the oropharynx. Histologically, 41% (7/17) of the successfully genotyped blocks were squamous cell carcinomas (larynx 6, maxillary sinus 1). Results and Conclusion We were unable to detect HPV in any of the HNC samples in our study. Our result may suggest that there is a low prevalence of HPV-related HNC among the adult population in Nigeria. Our results provide a benchmark to compare future incidence of HPV-related HNC in this community in future. We had significant analytical challenges from possible poor tissue processing and urge that future studies should prospectively collect samples and ensure high quality sample processing.
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页数:9
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