Synthesis, structure, photoluminescence and antitumour activity of zinc complex based on 2-(2-(1H-benzo-[d]imidazol-2-yl)benzyl)-1H-benzo-[d]imidazole

被引：15

作者：

Che, Zhijian ^{[1
]}

Wang, Shaoxiang ^{[2
]}

Liu, Shenggui ^{[1
]}

Li, Guobi ^{[1
]}

Wu, Qiting ^{[1
]}

Lin, Chunyu ^{[1
]}

Kong, Linglang ^{[1
]}

Wang, Sheng ^{[1
]}

机构：

[1] Lirzgnan Normal Univ, Sch Chem & Chem Engn, Zhanjiang 524048, Peoples R China

[2] Shenzhen Univ, Sch Med, Inst Mol Med, Shenzhen 518060, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2015年 / 135卷

关键词：

Benzimidazole; Zinc complex; Crystal structure; Luminescence; Antitumour activity; ESOPHAGEAL CANCER; CARCINOMA-CELLS; DNA-BINDING; DERIVATIVES; DEFICIENCY; APOPTOSIS; MELANOMA;

D O I：

10.1016/j.saa.2014.07.098

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A new complex [Zn(bbb)Cl-2].DMF, where bbb is 2-(2-(1H-benzo[d]imidazol-2-yl)benzyl)-1H-benzo[d]imidazole, was synthesized and characterized by element analysis, H-1 NMR and X-ray single crystal structure analyses. For complex: crystal system, triclinic, space group, P-1, a = 9.4661(13), b = 10.3534(14), c = 13.0025(18) angstrom, alpha = 73.477(2), beta = 80.743(2), gamma = 88.658(2)degrees, V= 1205.5(3) angstrom(3), Z= 2. In this complex, the Zn2+ distorted tetrahedron geometry is coordinated by two nitrogen atoms from 2(2-(1H-benzo[d]imidazol-2-yl)benzyl)-1H-benzo[d]imidazole and two Cl-. The complex emits yellow green luminescence with the maximal emission peak at 550 nm in DMF solution. The complex exhibits inhibition on the growth of Eca 109 cancer cell with IC50 value of 8.9 +/- 1.1 mu M, which was lower than that of cisplatin (14.3 +/- 1.4 mu M). This complex has potential application in treatment of esophageal cancer. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：878 / 882

页数：5

共 15 条

[11]

Sheldrick G.M., 1993, PROGRAM CRYSTAL STRU

[12] Zinc: a multipurpose trace element [J].

Stefanidou, M ;

Maravelias, C ;

Dona, A ;

Spiliopoulou, C .

ARCHIVES OF TOXICOLOGY, 2006, 80 (01) :1-9

[13] Nickel, copper, and zinc centered ruthenium-substituted porphyrins: effect of transition metals on photoinduced DNA cleavage and photoinduced melanoma cell toxicity [J].

Sweigert, Patrick ;

Xu, Zhiming ;

Hong, Yiling ;

Swavey, Shawn .

DALTON TRANSACTIONS, 2012, 41 (17) :5201-5208

[14] DNA binding and antiproliferative activity toward human carcinoma cells of copper(II) and zinc(II) complexes of a 2,5-diphenyl[1,3,4]oxadiazole derivative [J].

Terenzi, Alessio ;

Fanelli, Mirco ;

Ambrosi, Gianluca ;

Amatori, Stefano ;

Fusi, Vieri ;

Giorgi, Luca ;

Liveri, Vincenzo Turco ;

Barone, Giampaolo .

DALTON TRANSACTIONS, 2012, 41 (15) :4389-4395

[15] Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation [J].

Xie, Qiang ;

Liu, Shenggui ;

Li, Xiaoling ;

Wu, Qiong ;

Luo, Zuandi ;

Fu, Xiaoyan ;

Cao, Wenqiang ;

Lan, Guoqiang ;

Li, Dan ;

Zheng, Wenjie ;

Chen, Tianfeng .

DALTON TRANSACTIONS, 2014, 43 (19) :6973-6976

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