Pregnancy outcomes after maternal betahistine exposure: A case series

被引：3

作者：

Buharalioglu, Cuneyt Kemal ^{[1
]}

Acar, Selin ^{[2
,3
]}

Erol-Coskun, Hilal ^{[2
,3
]}

Kucuksolak, Gozde ^{[2
]}

Karadas, Baris ^{[2
,3
]}

Kaya-Temiz, Tijen ^{[2
,3
]}

Kaplan, Yusuf Cem ^{[2
,3
]}

机构：

[1] Izmir Kahp Celebi Univ, Dept Pharmacol, Fac Pharm, Balatcik Mahallesi Havaalani Sosesi 33-2, TR-35620 Izmir, Turkey

[2] Terafar Izmir Katip Celebi Univ Teratol Informat, Training & Res Ctr, Izmir, Turkey

[3] Izmir Katip Celebi Univ, Dept Pharmacol, Sch Med, Izmir, Turkey

来源：

REPRODUCTIVE TOXICOLOGY | 2018年 / 79卷

关键词：

Betahistine; Pregnancy; Congenital abnormalities; Birth defects; Pregnancy outcomes; Antivertigo drug; PATENT FORAMEN OVALE; MENIERES-DISEASE; MALROTATION; PREVALENCE; INFANTS; SAFETY;

D O I：

10.1016/j.reprotox.2018.06.004

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective: To investigate the pregnancy outcomes of women who were exposed to betahistine during their pregnancies. Methods: We identified and evaluated the outcomes of 27 pregnant women who were referred to Terafar (Teratology Information Service, Izmir, Turkey) for a teratological risk assessment. Results: Of 24 pregnancies with known outcomes, 21 resulted in live births (including two pairs of twins) whereas two ended with miscarriage and three with elective terminations. Among the 20 live births for whom the malformation details were available, there were 17 normal outcomes, one major and two minor congenital malformations. Conclusions: Despite a number of limitations, this case series may be of value regarding counseling pregnant women with inadvertent betahistine exposure. Further epidemiological studies with larger sample sizes and control groups are necessary to draw more definite conclusions.

引用

页码：79 / 83

页数：5

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