Synthesis utilizing insoluble polymers: new reactions and small molecules

被引：14
作者：
Baxter, AD [1 ]
机构：
[1] Oxford Divers, Abingdon OX14 4RX, Oxon, England
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 1997年 / 1卷 / 01期
关键词：
D O I：
10.1016/S1367-5931(97)80112-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
It can be argued that solid-phase organic chemistry is the preferred method of preparing screening libraries for lead compound discovery and lead optimization within the pharmaceutical industry, Solid-phase peptide chemistry is the most reliable and general of the synthetic methods available today; however, the purities of products are inadequate for the needs of the current market and the screening departments of pharmaceutical companies. Recent synthetic advances in solid-phase organic chemistry have started to increase the range of chemistry that can be used to prepare 'drug-like' small molecules in library format.
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页码：79 / 85
页数：7
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