Targeting CCN Proteins in Rheumatoid Arthritis and Osteoarthritis

被引：34

作者：

MacDonald, Iona J. ^{[1
]}

Huang, Chien-Chung ^{[2
,3
]}

Liu, Shan-Chi ^{[4
]}

Lin, Yen-You ^{[1
]}

Tang, Chih-Hsin ^{[1
,2
,5
,6
,7
]}

机构：

[1] China Med Univ, Grad Inst Basic Med Sci, Coll Med, Taichung 40402, Taiwan

[2] China Med Univ, Sch Med, Coll Med, Taichung 406040, Taiwan

[3] China Med Univ Hosp, Dept Internal Med, Div Immunol & Rheumatol, Taichung 404332, Taiwan

[4] China Med Univ, Beigang Hosp, Dept Med Educ & Res, Taichung 65152, Yunlin, Taiwan

[5] China Med Univ, Grad Inst Biomed Sci, Coll Med, Taichung 406040, Taiwan

[6] China Med Univ, Chinese Med Res Ctr, Taichung 406040, Taiwan

[7] Asia Univ, Dept Biotechnol, Coll Hlth Sci, Taichung 413305, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 09期

关键词：

CCN proteins; CCN family; rheumatoid arthritis; osteoarthritis; juvenile idiopathic arthritis; TISSUE-GROWTH-FACTOR; FIBROBLAST-LIKE SYNOVIOCYTES; MONOCYTE CHEMOATTRACTANT PROTEIN-1; SIGNALING PATHWAY PROTEIN-3; ARTICULAR-CARTILAGE; IL-6; PRODUCTION; EXPRESSION; CYR61; INHIBITION; COMMUNICATION;

D O I：

10.3390/ijms22094340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CCN family of matricellular proteins (CYR61/CCN1, CTGF/CCN2, NOV/CCN3 and WISP1-2-3/CCN4-5-6) are essential players in the key pathophysiological processes of angiogenesis, wound healing and inflammation. These proteins are well recognized for their important roles in many cellular processes, including cell proliferation, adhesion, migration and differentiation, as well as the regulation of extracellular matrix differentiation. Substantial evidence implicates four of the proteins (CCN1, CCN2, CCN3 and CCN4) in the inflammatory pathologies of rheumatoid arthritis (RA) and osteoarthritis (OA). A smaller evidence base supports the involvement of CCN5 and CCN6 in the development of these diseases. This review focuses on evidence providing insights into the involvement of the CCN family in RA and OA, as well as the potential of the CCN proteins as therapeutic targets in these diseases.

引用

页数：13